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Alcohol-related brain damage [1] [2] alters both the structure and function of the brain as a result of the direct neurotoxic effects of alcohol intoxication or acute alcohol withdrawal. Increased alcohol intake is associated with damage to brain regions including the frontal lobe , [ 3 ] limbic system , and cerebellum , [ 4 ] with widespread ...
Alcohol-related dementia can produce a variety of psychiatric problems including psychosis (disconnection from reality), depression, anxiety, and personality changes. Patients with alcoholic dementia often develop apathy, related to frontal lobe damage, that may mimic depression. [3]
Alcohol acts as a general central nervous system depressant, but it also affects some specific areas of the brain to a greater extent than others. Memory impairment caused by alcohol has been linked to the disruption of hippocampal function—particularly affecting gamma-Aminobutyric acid (GABA) and N-methyl-D-aspartate (NMDA) neurotransmission which negatively impacts long-term potentiation ...
the frontal lobe. In addition to the damage seen in these areas there have been reports of damage to cortex, although it was noted that this may be due to the direct toxic effects of alcohol as opposed to thiamine deficiency that has been attributed as the underlying cause of Wernicke-Korsakoff Syndrome. [26]
Diet and lifestyle can also play a part. "Very low levels of sodium in the body, extreme sleep deprivation, very low blood sugar or alcohol withdrawal can trigger sporadic seizures," says Shih ...
Frontotemporal dementia is the overarching term used to describe a collection of brain diseases associated with the frontal and temporal lobes which affect language, personality and behavior ...
“Alcohol can also increase the desire to socialize while disrupting circuits in the frontal lobes involved in controlling impulses and making decisions,” says White.
The long-term impact of alcohol on the brain has become a growing area of research focus. While researchers have found that moderate alcohol consumption in older adults is associated with better cognition and well-being than abstinence, [1] excessive alcohol consumption is associated with widespread and significant brain lesions.