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IARC group 1 Carcinogens are substances, chemical mixtures, and exposure circumstances which have been classified as carcinogenic to humans by the International Agency for Research on Cancer (IARC). [1] This category is used when there is sufficient evidence of carcinogenicity in humans.
The following is a list of chemicals published as a requirement of Safe Drinking Water and Toxic Enforcement Act of 1986, commonly known as California Proposition 65, that are "known to the state to cause cancer or reproductive toxicity" as of January 3, 2020. [1]
Ted S. Gansler, the director of medical content for the American Cancer Society, stated "There is no convincing evidence that antiperspirant or deodorant use increases cancer risk". [6] However, there is continued concern over the use of aluminium chlorohydrate in cosmetics as the risk of toxic build up over time has not been ruled out. [8]
Aluminium chloride, also known as aluminium trichloride, is an inorganic compound with the formula AlCl 3. It forms a hexahydrate with the formula [Al(H 2 O) 6 ]Cl 3 , containing six water molecules of hydration .
The IARC Monographs on which this list is based assess the hazard linked to the agents, they do not assess the cancer risk of the agents. [1] The list is up-to-date as of January 2024. [ 2 ]
Industrial processes associated with cancer include aluminum production; iron and steel founding; and underground mining with exposure to uranium or radon. Shift work, which can disturb the circadian rhythm, has also been identified as a risk factor for some forms of cancer, in particular for breast cancer. [3] [4] [5]
Cancer slope factors (CSF) are used to estimate the risk of cancer associated with exposure to a carcinogenic or potentially carcinogenic substance. A slope factor is an upper bound, approximating a 95% confidence limit , on the increased cancer risk from a lifetime exposure to an agent by ingestion or inhalation .
A risk score is a metric used in statistics, biostatistics, econometrics and related disciplines to stratify a population for targeted screening. It assigns scores to ...