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The Radial Unit Hypothesis (RUH) is a conceptual theory of cerebral cortex development, first described by Pasko Rakic. It states that the cerebral cortex develops during embryogenesis as an array of interacting cortical columns , or 'radial units', each of which originates from a transient stem cell layer called the ventricular zone , which ...
The marginal zone is the region at the interface between the non-lymphoid red pulp and the lymphoid white-pulp of the spleen. (Some sources consider it to be the part of red pulp which borders on the white pulp, while other sources consider it to be neither red pulp nor white pulp.) A marginal zone also exists in the lymphoid follicles of lymph ...
A marginal probability can always be written as an expected value: = () = [()]. Intuitively, the marginal probability of X is computed by examining the conditional probability of X given a particular value of Y , and then averaging this conditional probability over the distribution of all values of Y .
Cajal–Retzius cells were described to migrate tangentially in the marginal zone, a superficial layer of the preplate in the cortical neuroepithelium, [3] [4] According to some studies, this migration depends on the site where the cell was generated, showing a link between the origin, the migration and the destination of the cell. [5]
The ventricular and subventricular zones exist inferior to the intermediate zone and communicate with other zones through cell signalling. These zones additionally create neurons destined to migrate to other areas in the cortex. [1] [6] The marginal zone, along with the cortical zone, make up the 6 layers that form the cortex. This zone is the ...
A marginal likelihood is a likelihood function that has been integrated over the parameter space.In Bayesian statistics, it represents the probability of generating the observed sample for all possible values of the parameters; it can be understood as the probability of the model itself and is therefore often referred to as model evidence or simply evidence.
In humans the splenic marginal zone B cells have evidence of somatic hypermutation in their immunoglobulin genes, indicating that they have been generated through a germinal centre reaction to become memory cells. While naive MZ B cells produce low-affinity IgM antibodies, memory MZ B cells express high-affinity Ig molecules.
The subplate, also called the subplate zone, together with the marginal zone and the cortical plate, in the fetus represents the developmental anlage of the mammalian cerebral cortex. It was first described, as a separate transient fetal zone by Ivica Kostović and Mark E. Molliver in 1974.