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EGF-like module-containing mucin-like hormone receptor-like 1 also known as F4/80 is a ... F4/80 is not necessary for the development of tissue macrophages but is ...
They can be identified using flow cytometry or immunohistochemical staining by their specific expression of proteins such as CD14, CD40, CD11b, CD64, F4/80 (mice)/EMR1 (human), lysozyme M, MAC-1/MAC-3 and CD68. [9] Macrophages were first discovered and named by Élie Metchnikoff, a Russian Empire zoologist, in 1884. [10] [11]
Macrophages displaying M1 phenotype have been characterized by expression of F4/80, CD11c and iNOS whereas macrophages displaying M2 phenotype have been characterized by expression of F4/80, CD301 and Arg1. [10] Adiopose tissue macrophage polarization was summarized in a review article Appari M et al., et al. [11]
He began his studies on macrophages while in the laboratory of Zanvil Cohn at Rockefeller University in 1966. Upon his move to the Sir William Dunn School of Pathology at University of Oxford in 1976 he continued this work and identified the pan-macrophage marker F4/80.
The islet resident macrophage was first identified in 1979 as an antigen-presenting cell (APC), [9] which expresses major histocompatibility complexes (MHCs). Later in 1984 this APC was further classified by using a macrophage specific marker F4/80. [10]
These cords are made up of fibroblasts and reticular fibres which form an open blood system without an endothelial lining, and it is within these cords that F4/80+ macrophages are found, which are associated with the reticular cells of these areas and are collectively known as red pulp macrophages.
Dermal macrophages’ expression of cell markers like CD11b, F4/80 and MHC II indicate their participation in the MHC II antigen-presenting pathway. [ 5 ] [ 3 ] However, the MHC II expression is low compared to Langerhans cells, rendering dermal macrophages minor contributors to antigen presentation.
[6] [7] Macrophages have also been found in the testes of humans, [8] guinea pigs, hamsters, [9] boars, [10] horses [11] and bulls. [12] They originate from blood monocytes which move into the testis then mature into macrophages. In the rat, testicular macrophages have been described as either “resident” or “newly arrived” from the ...