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2'-O-methylation (2'-O-Me) is a common nucleotide epitranscriptomics modification of ribosomal RNA (rRNA). The rRNA is transcribed from DNA and then used to create proteins through translation. [1] The resulting protein would normally be solely dependent on the gene it was translated from, but the methylation of the RNA would influence the ...
Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. [1] U16 is predicted to guide the 2'O-ribose methylation of 18S ribosomal RNA (rRNA) residue A484 [2] and is encoded within an intron of the gene for ribosomal proteins L1 in animals. [3] This snoRNA was independently named MBII-98 ...
The template for methylation consists of 10-21 nucleotides. [38] 2'-O-methylation of the ribose sugar is one of the most common rRNA modifications. [40] Methylation is primarily introduced by small nucleolar RNA's, referred to as snoRNPs. There are two classes of snoRNPs that target methylation sites, and they are referred to box C/D and box H/ACA.
Most of the members of the box C/D family function in directing site-specific 2′-O-methylation of substrate RNAs. [1] SNORD111 is predicted to guide the 2′O-ribose methylation of 28S ribosomal RNA (rRNA) at residue G3923. [2] [3] The exact role of these molecules, however, is not currently known.
Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. [1] This snoRNA was originally cloned from HeLa cells and expression verified by northern blotting. [2] It is predicted to guide 2'O-ribose methylation of ribosomal RNA (rRNA) 28S at residue C3866.
This snoRNA is the human orthologue of mouse snoRNA MBII-336. [2] SNORD93 is predicted to guide the 2'O-ribose methylation of 18S ribosomal RNA (rRNA) residue A576. [ 3 ] Additionally, SNORD93 can be processed into a smaller, microRNA-like fragment (termed snoRNA-derived RNA(sdRNA)) that contributes to the malignant phenotype of breast cancer ...
Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. [1] TBR7 was one of seventeen snoRNAs identified in Trypanosoma brucei by immunoprecipitation with anti-fibrillarin antibodies. [2] It is predicted to guide the 2'O ribosome methylation of 18s ribosomal RNA (rRNA).
Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. [1] snoRNA HBII-166 is the human orthologue of the mouse MBII-166 [2] and is predicted to guide 2'O-ribose methylation of spliceosomal RNA U6 at residue C60. [3]