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  2. Hemolytic disease of the newborn (anti-Kell) - Wikipedia

    en.wikipedia.org/wiki/Hemolytic_disease_of_the...

    Anti-Kell can cause severe anemia regardless of titer. [13] Anti-Kell suppresses the bone marrow, [14] by inhibiting the erythroid progenitor cells. [15] [16] anti-Kell 2, anti-Kell 3 and anti-Kell 4 antibodies. Hemolytic disease of the newborn can also be caused by anti-Kell 2, anti-Kell 3 and anti-Kell 4 IgG antibodies. These are rarer and ...

  3. Kell antigen system - Wikipedia

    en.wikipedia.org/wiki/Kell_antigen_system

    Kell antigens are important in transfusion medicine, autoimmune hemolytic anemia and hemolytic disease of the newborn (anti-Kell). Anti-K is the next most common immune red cell antibody after those in the ABO and Rh system. Anti-K typically presents as IgG class alloantibody. Individuals lacking a specific Kell antigen may develop antibodies ...

  4. Hemolytic disease of the newborn - Wikipedia

    en.wikipedia.org/wiki/Hemolytic_disease_of_the...

    Anti-Kell hemolytic disease of the newborn is most commonly caused by anti-K 1 antibodies, the second most common form of severe HDN. Over half of the cases of anti-K 1 related HDN are caused by multiple blood transfusions. Antibodies to the other Kell antigens are rare. [19] Anti-Kell can cause severe anemia regardless of titer. [22]

  5. Delayed hemolytic transfusion reaction - Wikipedia

    en.wikipedia.org/wiki/Delayed_hemolytic...

    Antibodies against Kidd antigens may be difficult to detect because of significant variability in their molecular features, and weak in vitro expression. They have been reported to cause severe immediate or delayed hemolytic transfusion reactions, [6] with anti-Jk antibodies responsible for 13 of 44 cases of DHTR reported in the UK during 2021. [7]

  6. Acute hemolytic transfusion reaction - Wikipedia

    en.wikipedia.org/wiki/Acute_hemolytic...

    An acute hemolytic transfusion reaction (AHTR), also called immediate hemolytic transfusion reaction, is a life-threatening reaction to receiving a blood transfusion. AHTRs occur within 24 hours of the transfusion and can be triggered by a few milliliters of blood. The reaction is triggered by host antibodies destroying donor red blood cells.

  7. Acquired hemolytic anemia - Wikipedia

    en.wikipedia.org/wiki/Acquired_hemolytic_anemia

    Anti-Kell hemolytic disease of the newborn [1] Rhesus c hemolytic disease of the newborn [1] Rhesus E hemolytic disease of the newborn [1] Other blood group incompatibility (RhC, Rhe, Kidd, Duffy, MN, P and others) [1] Alloimmune hemolytic blood transfusion reactions (i.e., from a non-compatible blood type) [1]

  8. Monocyte monolayer assay - Wikipedia

    en.wikipedia.org/wiki/Monocyte_monolayer_assay

    There are many different varieties of abnormal reactions to blood transfusion. Among these, a potentially life-threatening reaction is known as a hemolytic transfusion reaction. This is an immune mediated reaction where recipient antibodies attack donor red blood cell antigen(s), causing hemolysis of donor cells.

  9. McLeod syndrome - Wikipedia

    en.wikipedia.org/wiki/McLeod_syndrome

    McLeod syndrome was discovered in 1961 and, similar to the Kell antigen system, was named after the first patient in which it was discovered; a dental student by the name of Hugh McLeod. McLeod's red blood cells demonstrated a peculiar appearance when viewed microscopically ( acanthocytic (spiky)) and showed weak expression of Kell system antigens.