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Clobetasol propionate is a corticosteroid that is used to treat skin conditions such as eczema, contact dermatitis, seborrheic dermatitis, steroid responsive dermatosis, and psoriasis (including scalp and plaque-type). [8] [9] It is applied to the skin as a cream, foam, gel, liquid, solution, ointment, or shampoo.
Clobetasol is a synthetic glucocorticoid corticosteroid. A propionate ester of clobetasol, clobetasol propionate , has also been marketed, and is far more widely used in comparison. [ 2 ] [ 3 ]
Clobetasol propionate 0.05% (Dermovate) Betamethasone dipropionate 0.25% (Diprolene) Halobetasol propionate 0.05% (Ultravate, Halox) Diflorasone diacetate 0.05% (Psorcon)
Topical Clobetasol Propionate 0.05% cream is usually used and applied twice daily. A study by Joly et al. demonstrated that the use of 10 to 20g of Clobetasol Propionate per day for moderate disease and 20 to 30g per day for extensive disease until 15 days after disease control, then tapered to discontinuation over four months was as effective ...
Menter MA, Caveney SW, Gottschalk RW (Nov 2012). "Impact of clobetasol propionate 0.05% spray on health-related quality of life in patients with plaque psoriasis". review. Journal of Drugs in Dermatology. 11 (11): 1348– 54. PMID 23135087. Osier E, Gomez B, Eichenfield LF (Jul 2015).
In dermatology, topical clobetasone butyrate helps to reduce the itchiness and erythema associated with eczema and dermatitis. [5]In ophthalmology, clobetasone butyrate 0.1% eye drops have been shown to be safe and effective in the treatment of dry eyes in Sjögren syndrome.
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These patents expired in 2003 and 2007 respectively leading to generic production of betamethasone dipropionate. During this time other topical corticosteroids such as triamcinolone acetonide and clobetasol propionate also became available as generic creams. Merck filed for "pediatric exclusivity" in 2001 launching a clinical trial to prove ...
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