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  2. Hexokinase - Wikipedia

    en.wikipedia.org/wiki/Hexokinase

    A hexokinase is an enzyme that irreversibly phosphorylates hexoses (six-carbon sugars), forming hexose phosphate. In most organisms, glucose is the most important substrate for hexokinases, and glucose-6-phosphate is the most important product. Hexokinase possesses the ability to transfer an inorganic phosphate group from ATP to a substrate.

  3. Hexokinase II - Wikipedia

    en.wikipedia.org/wiki/Hexokinase_II

    Hexokinase II, also known as Hexokinase B and HK2, is an enzyme which in humans is encoded by the HK2 gene on chromosome 2. [5] [6] Hexokinases phosphorylate glucose to produce glucose 6-phosphate, the first step in most glucose metabolism pathways. Hexokinase II is the predominant hexokinase form found in skeletal muscle.

  4. Polyol pathway - Wikipedia

    en.wikipedia.org/wiki/Polyol_pathway

    The polyol metabolic pathway. [6]Cells use glucose for energy.This normally occurs by phosphorylation from the enzyme hexokinase. However, if large amounts of glucose are present (as in diabetes mellitus), hexokinase becomes saturated and the excess glucose enters the polyol pathway when aldose reductase reduces it to sorbitol.

  5. Phosphorylation - Wikipedia

    en.wikipedia.org/wiki/Phosphorylation

    [clarification needed] The hexokinase enzyme has a low Michaelis constant (K m), indicating a high affinity for glucose, so this initial phosphorylation can proceed even when glucose levels at nanoscopic scale within the blood.

  6. Glucokinase regulatory protein - Wikipedia

    en.wikipedia.org/wiki/Glucokinase_regulatory_protein

    The glucokinase regulatory protein (GKRP) also known as glucokinase (hexokinase 4) regulator (GCKR) is a protein produced in hepatocytes (liver cells). GKRP binds and moves glucokinase (GK), thereby controlling both activity and intracellular location [1] [2] of this key enzyme of glucose metabolism. [3] GKRP is a 68 kD protein of 626 amino acids.

  7. Hexokinase III - Wikipedia

    en.wikipedia.org/wiki/Hexokinase_III

    Hexokinase III, also known as hexokinase C, is an enzyme which in humans is encoded by the Hk3 gene on chromosome 5. [ 5 ] [ 6 ] Hexokinases phosphorylate glucose to produce glucose-6-phosphate , the first step in most glucose metabolism pathways.

  8. PKM2 - Wikipedia

    en.wikipedia.org/wiki/PKM2

    PKM2 is a cytosolic enzyme that is associated with other glycolytic enzymes, i.e., hexokinase, glyceraldehyde 3-P dehydrogenase, phosphoglycerate kinase, phosphoglyceromutase, enolase, and lactate dehydrogenase within a so-called glycolytic enzyme complex. [25] [31] [32] [33]

  9. Hexokinase I - Wikipedia

    en.wikipedia.org/wiki/Hexokinase_I

    Hexokinase I, also known as hexokinase A and HK1, is an enzyme that in humans is encoded by the HK1 gene on chromosome 10. Hexokinases phosphorylate glucose to produce glucose-6-phosphate (G6P), the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of ...