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2. Metformin - Wikipedia

   en.wikipedia.org/wiki/Metformin

   [9] [131] Peak plasma concentrations (C max) are reached within 1–3 hours of taking immediate-release metformin and 4–8 hours with extended-release formulations. [ 9 ] [ 131 ] The plasma protein binding of metformin is negligible, as reflected by its very high apparent volume of distribution (300–1000 L after a single dose).

3. Is There a "Best Time" to Take Metformin? - AOL

   www.aol.com/best-time-metformin-115700262.html

   Further, metformin comes in the form of immediate-release tablets, extended-release tablets, and as a liquid. Each type of metformin has different requirements in terms of when and how to take it:

4. Modified-release dosage - Wikipedia

   en.wikipedia.org/wiki/Modified-release_dosage

   Modified-release dosage is a mechanism that (in contrast to immediate-release dosage) delivers a drug with a delay after its administration (delayed-release dosage) or for a prolonged period of time (extended-release [ER, XR, XL] dosage) or to a specific target in the body (targeted-release dosage). [1]

5. Pharmaceutical formulation - Wikipedia

   en.wikipedia.org/wiki/Pharmaceutical_formulation

   A capsule is a gelatinous envelope enclosing the active substance. Capsules can be designed to remain intact for some hours after ingestion in order to delay absorption. They may also contain a mixture of slow and fast release particles to produce rapid and sustained absorption in the same dose.

6. Depot injection - Wikipedia

   en.wikipedia.org/wiki/Depot_injection

   Most commonly, depot injections are designed to have a duration of 2–4 weeks of action, [5] however the pharmacokinetics of a specific formulation vary. Absorption and metabolism can both be affected by modifying the drug itself (for example, by attaching a functional group ) or by the formulation of the product (examples are oil or ...

7. Diabetes medication - Wikipedia

   en.wikipedia.org/wiki/Diabetes_medication

   Metformin is a first-line medication used for treatment of type 2 diabetes. It is generally prescribed at initial diagnosis in conjunction with exercise and weight loss, as opposed to the past, where it was prescribed after diet and exercise had failed.