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The International Agency for Research on Cancer (IARC) rendered PCBs as definite carcinogens in humans. According to the U.S. Environmental Protection Agency (EPA), PCBs cause cancer in animals and are probable human carcinogens. [4] Moreover, because of their use as a coolant in electric transformers, PCBs still persist in built environments ...
Exposure to the coplanar stereoisomer 3,3',4,4',5,5'-hexabromobiphenyl (but not the non-coplanar stereoisomer) in genetically susceptible mice is known to cause immunotoxicity and disorders related to the central nervous system, and even at doses as low as 2.5 mg/kg, excess neonatal fatalities are observed (LD 50 is from 5–10 mg/kg). [1]
Bioremediation of PCBs is the use of microorganisms to degrade PCBs from contaminated sites, relying on multiple microorganisms' co-metabolism. Anaerobic microorganisms dechlorinate PCBs first, and other microorganisms that are capable of doing BH pathway can break down the dechlorinated PCBs to usable intermediates like acyl-CoA or carbon ...
No harmful levels of carcinogenic PCBs were found inside the missile launch facilities at F.E. Warren Air Force base in Wyoming, the service said Tuesday, as it looks for possible causes for ...
Test results conducted in the fall showed the presence of PCBs, or polychlorinated biphenyls — toxic, man-made chemicals that were banned from being produced in the United States in 1979 ...
Certain canned foods and plastic containers could cause cancer -- and those aren't the only potential dangers lurking in your home.
The highest TCDD levels were found in children, up to 56,000 pg/g fat. Acute effects were limited to chloracne, although many animals such as rabbits died after eating contaminated grass. [29] Dental aberrations were found after 25 years in persons exposed as children, and a slightly increased cancer risk was confirmed 35 years later. [1]
This genotoxic mechanism may interact in synergy with estrogen receptor-mediated, persistent cell proliferation to ultimately cause breast cancer. [49] Genetic background, dietary practices and environmental factors also likely contribute to the incidence of DNA damage and breast cancer risk.