Search results
Results from the WOW.Com Content Network
The profile-based fold recognition approach was first described by Bowie, Lüthy and David Eisenberg in 1991. [1] The term threading was first coined by David Jones, William R. Taylor and Janet Thornton in 1992, [2] and originally referred specifically to the use of a full 3-D structure atomic representation of the protein template in fold ...
Remote template detection, single-template and multi-template threading, totally different from and much better than the old program RAPTOR designed by the same group: Webserver with job manager, automatically updated fold library HHpred: Template detection, alignment, 3D modeling: Interactive webserver with help facility Phyre, Phyre2
In functional programming, fold (also termed reduce, accumulate, aggregate, compress, or inject) refers to a family of higher-order functions that analyze a recursive data structure and through use of a given combining operation, recombine the results of recursively processing its constituent parts, building up a return value.
Homology model of the DHRS7B protein created with Swiss-model and rendered with PyMOL. Homology modeling, also known as comparative modeling of protein, refers to constructing an atomic-resolution model of the "target" protein from its amino acid sequence and an experimental three-dimensional structure of a related homologous protein (the "template").
However, the fold library database increases by about 40-100 new structures each week. So even though there might be no decent templates this week, there may well be in the coming weeks. Phyrealarm allows users to submit a protein sequence to be automatically scanned against new entries added to the fold library every week.
The goal of protein design is to find a protein sequence that will fold to a target structure. A protein design algorithm must, thus, search all the conformations of each sequence, with respect to the target fold, and rank sequences according to the lowest-energy conformation of each one, as determined by the protein design energy function.
Get AOL Mail for FREE! Manage your email like never before with travel, photo & document views. Personalize your inbox with themes & tabs. You've Got Mail!
In bioinformatics, the template modeling score or TM-score is a measure of similarity between two protein structures.The TM-score is intended as a more accurate measure of the global similarity of full-length protein structures than the often used RMSD measure.