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2. Nebulizer - Wikipedia

   en.wikipedia.org/wiki/Nebulizer

   This inhaler, known as "Siegle's steam spray inhaler", used the Venturi principle to atomize liquid medication, and this was the very beginning of nebulizer therapy. The importance of droplet size was not yet understood, so the efficacy of this first device was unfortunately mediocre for many of the medical compounds.

3. Dorzolamide/timolol - Wikipedia

   en.wikipedia.org/wiki/Dorzolamide/timolol

   Specifically, the mean reduction in intraocular pressure was 27.4% for the combination product, 15.5% for dorzolamide 2%, and 22.2% for timolol 0.5%. Compared to other products such as latanoprost, both are equally efficacious with regard to lowering intraocular pressure and getting patients to reach their target intraocular pressure. [ 14 ]

4. Median lethal dose - Wikipedia

   en.wikipedia.org/wiki/Median_lethal_dose

   The concept of Ct was first proposed by Fritz Haber and is sometimes referred to as Haber's law, which assumes that exposure to 1 minute of 100 mg/m 3 is equivalent to 10 minutes of 10 mg/m 3 (1 × 100 = 100, as does 10 × 10 = 100). Some chemicals, such as hydrogen cyanide, are rapidly detoxified by the human body, and do not follow Haber's law.