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mRNA in vitro transcription, innate and adaptive immunity activation. An mRNA vaccine is a type of vaccine that uses a copy of a molecule called messenger RNA (mRNA) to produce an immune response. [1]
The mRNA vaccines made by Pfizer-BioNTech and Moderna were both designed within weeks of the release of the SARS-CoV-2 coronavirus genome, and first to come off manufacturing lines for worldwide use.
The duo's pivotal mRNA research was combined with two other earlier scientific discoveries to create the COVID-19 vaccines. Researchers in Canada had developed a fatty coating to help mRNA get ...
In the late 1980s, while a graduate student researcher at the Salk Institute for Biological Studies in San Diego, California, Malone conducted studies on messenger ribonucleic acid technology, discovering in what Nature has described as a landmark experiment that it was possible to transfer mRNA protected by a liposome into cultured cells to signal the information needed for the production of ...
Two pioneering scientists who created the technology behind life-saving Covid-19 vaccines have won the Nobel Prize in medicine or physiology.
One site of mRNA translation is at polyribosomes selectively localized beneath synapses. [11] The mRNA for Arc/Arg3.1 is induced by synaptic activity and localizes selectively near active synapses based on signals generated by NMDA receptors. [12] Other mRNAs also move into dendrites in response to external stimuli, such as β-actin mRNA. [13]
Drew Weissman (born September 7, 1959) is an American physician and immunologist known for his contributions to RNA biology. Weissman is the inaugural Roberts Family Professor in Vaccine Research, director of the Penn Institute for RNA Innovation, and professor of medicine at the Perelman School of Medicine at the University of Pennsylvania (Penn).
The beauty of mRNA technology is that it opens the door to a more personalized and effective treatment as messenger RNA instructs the patient’s cells how to combat diseases like cancer.
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