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  2. Rivaroxaban - Wikipedia

    en.wikipedia.org/wiki/Rivaroxaban

    Rivaroxaban, sold under the brand name Xarelto among others, is an anticoagulant medication (blood thinner) used to treat and prevent blood clots. [8] Specifically it is used to treat deep vein thrombosis and pulmonary emboli and prevent blood clots in atrial fibrillation and following hip or knee surgery. [ 8 ]

  3. Bayer's patent for blood thinner Xarelto invalid, UK court rules

    www.aol.com/news/bayers-patent-blood-thinner...

    The company's blockbuster Xarelto drug generated nearly $4.1 billion in revenue in 2023, according to research firm Statista. ... 15mg and 20mg generic rivaroxaban products," a Bayer spokesperson ...

  4. Discovery and development of direct Xa inhibitors - Wikipedia

    en.wikipedia.org/wiki/Discovery_and_development...

    Rivaroxaban. During the SAR development of rivaroxaban, researchers realized that adding a 5-chlorothiophene-2-carboxamide group to the oxazolidonine core could increase the potency by 200 fold, which had previously been too weak for medical use. In addition to this discovery, a clear preference for the (S)-configuration was confirmed.

  5. Apixaban - Wikipedia

    en.wikipedia.org/wiki/Apixaban

    In December 2019, the US FDA approved a generic version of apixaban produced jointly by Mylan and Micro Labs. [ 33 ] [ 32 ] [ 8 ] BMS and Pfizer worked quickly to block generics from being created, and in August 2020, they won a patent infringement lawsuit against Sigmapharm , Sunshine Lake, and Unichem , after previously settling patent cases ...

  6. Dabigatran - Wikipedia

    en.wikipedia.org/wiki/Dabigatran

    In 2020, it was the 306th most commonly prescribed medication in the United States, with more than 1 million prescriptions. [11] Dabigatran is available a generic medication . [ 12 ] [ 13 ]

  7. Edoxaban - Wikipedia

    en.wikipedia.org/wiki/Edoxaban

    In human, 15–150 mg oral doses of edoxaban reach their maximum concentrations in blood 1–2 hours after ingestion. With 60 mg doses of isotope labeled edoxaban, 97% of the total radiation was detected after oral administration, with 62% from feces and 35% from urine. 49% of the total radiation from the feces and 24% from the urine were from ...

  8. List of Vocaloid products - Wikipedia

    en.wikipedia.org/wiki/List_of_Vocaloid_products

    Release date Leon [1] Zero-G Ltd: English Male January 15, 2004 March 3, 2004 (Japan) Lola [2] Female Miriam [3] Female Miriam Stockley: July 1, 2004 July 26, 2004 (Japan) MEIKO [4] Yamaha Corporation (developer) [5] Crypton Future Media (distributor) Japanese Female Meiko Haigō November 5, 2004 KAITO [6] Male Naoto Fūga February 17, 2006

  9. Etanercept - Wikipedia

    en.wikipedia.org/wiki/Etanercept

    51 235.07 g·mol −1 Etanercept , sold under the brand name Enbrel among others, is a biologic medical product that is used to treat autoimmune diseases by interfering with tumor necrosis factor (TNF), a soluble inflammatory cytokine, by acting as a TNF inhibitor .

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