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  2. Rivaroxaban - Wikipedia

    en.wikipedia.org/wiki/Rivaroxaban

    Rivaroxaban inhibits both free and bound Factor Xa in the prothrombinase complex. [33] It is a selective direct factor Xa inhibitor with an onset of action of 2.5 to 4 hours. [34] Inhibition of Factor Xa interrupts the intrinsic and extrinsic pathway of the blood coagulation cascade, inhibiting both thrombin formation and development of thrombi.

  3. Apixaban - Wikipedia

    en.wikipedia.org/wiki/Apixaban

    Apixaban, sold under the brand name Eliquis, is an anticoagulant medication used to treat and prevent blood clots and to prevent stroke in people with nonvalvular atrial fibrillation through directly inhibiting factor Xa.

  4. Riociguat - Wikipedia

    en.wikipedia.org/wiki/Riociguat

    One of the first studies was designed to test the safety profile, pharmacokinetics and pharmacodynamics of single oral doses of riociguat (0.25–5 mg). 58 healthy male subjects were given riociguat orally (oral solution or immediate-release tablet) in a randomised, placebo-controlled trial.

  5. Equianalgesic - Wikipedia

    en.wikipedia.org/wiki/Equianalgesic

    Equianalgesic charts are also used when calculating an equivalent dosage of the same drug, ... 2 ⁄ 5: 25 mg 3.2–3.8 hours ±4 hours Benzylfentanyl: 1 ...

  6. Vericiguat - Wikipedia

    en.wikipedia.org/wiki/Vericiguat

    After vericiguat is administered (100 mg by mouth once daily), the average steady state and Cmax and AUC for patients with cardiovascular failure is 350 mcg/L and 6,680 mcg/h/L with a Tmax of one hour. Vericiguat has a positive food effect, and therefore patients are advised to consume food with the drug for an oral bioavailability of 93%. [11]

  7. Isradipine - Wikipedia

    en.wikipedia.org/wiki/Isradipine

    [2] Cimetidine increased isradipine mean peak plasma levels. A downward dose adjustment may be necessary with this particular instance of polypharmacy. [2] Severe hypotension was reported with fentanyl anesthesia when it was combined with other calcium channel blockers. Even though isradipine, another calcium channel blocker, has not been used ...

  8. Levamlodipine - Wikipedia

    en.wikipedia.org/wiki/Levamlodipine

    Administration of levamlodipine (2.5 mg) as a single dose gives maximum plasma concentration (C max) of 8.3 to 9.3 ng/mL in 2 to 3 hrs (T max).It is extensively (about 90%) converted to inactive metabolites via hepatic metabolism with 10% of the parent compound and 60% of the metabolites excreted in the urine.

  9. Midodrine - Wikipedia

    en.wikipedia.org/wiki/Midodrine

    Midodrine, also known as 3,6-dimethoxy-β-hydroxy-N-aminoethanonyl-2-phenylethylamine, is a substituted phenethylamine derivative. [ 4 ] Midodrine is an odorless, white, crystalline powder, soluble in water and sparingly soluble in methanol .

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