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2. Methylnaltrexone - Wikipedia

   en.wikipedia.org/wiki/Methylnaltrexone

   Methylnaltrexone (MNTX, brand name Relistor), used in form of methylnaltrexone bromide (INN, USAN, BAN), is a medication that acts as a peripherally acting μ-opioid receptor antagonist that acts to reverse some of the side effects of opioid drugs such as constipation without significantly affecting pain relief or precipitating withdrawals.

3. Naloxegol - Wikipedia

   en.wikipedia.org/wiki/Naloxegol

   Naloxegol (INN; PEGylated naloxol; [4] trade names Movantik and Moventig) is a peripherally acting μ-opioid receptor antagonist developed by AstraZeneca, licensed from Nektar Therapeutics, for the treatment of opioid-induced constipation. [5] It was approved in 2014 in adult patients with chronic, non-cancer pain. [6]

4. Opiorphin - Wikipedia

   en.wikipedia.org/wiki/Opiorphin

   Such action extends the duration of enkephalin effect where the natural pain killers are released physiologically in response to specific potentially painful stimuli, in contrast with administration of narcotics, which floods the entire body and causes many undesirable adverse reactions, including addiction liability and constipation.

5. FDA approves opioid-free pain medication with 'no sign of ...

   www.aol.com/news/fda-approves-opioid-free-pain...

   The new drug is intended for treatment of moderate to severe acute pain in adults. Common Pain Reliever Could Cause Medical Complications In Some People Over 65, Study Suggests ... medications ...

6. FDA approves new type of non-opioid pain medication, 1st of ...

   www.aol.com/news/fda-approves-type-non-opioid...

   The U.S. Food and Drug Administration (FDA) on Thursday approved a new type of prescription pain medication for adults to treat moderate to severe acute pain. The drug, called Journavx ...

7. Codeine - Wikipedia

   en.wikipedia.org/wiki/Codeine

   Codeine is used to treat mild to moderate pain. [4] It is commonly used to treat post-surgical dental pain. [13]Weak evidence indicates that it is useful in cancer pain, but it may have increased adverse effects, especially constipation, compared to other opioids. [14]