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A sequela (UK: / s ɪ ˈ k w iː l ə /, [1] US: / s ɪ ˈ k w ɛ l ə /; [2] [3] usually used in the plural, sequelae /-iː /) is a pathological condition resulting from a disease, injury, therapy, or other trauma. Derived from the Latin word meaning "sequel", it is used in the medical field to mean a complication or condition following a ...
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Post-polio syndrome (PPS, poliomyelitis sequelae) is a group of latent symptoms of poliomyelitis (polio), occurring in more than 80% of polio infections. The symptoms are caused by the damaging effects of the viral infection on the nervous system and typically occur 15 to 30 years after an initial acute paralytic attack.
While it is commonly assumed that people either recover or die from infections, long-term symptoms—or sequelae—are a possible outcome as well. [1] Examples include long COVID (post-acute sequelae of SARS-CoV-2 infection, PASC), Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), and post-Ebola virus syndrome. [1]
[12] [13] While long COVID is the most prevalent name, the terms long-haul COVID, post-COVID-19 syndrome, post-COVID-19 condition, [1] [14] post-acute sequelae of COVID-19 (PASC), and chronic COVID syndrome are also in use. [5] Long COVID may not be a single disease or syndrome.
Complications are not to be confused with sequelae, which are residual effects that occur after the acute (initial, most severe) [1] phase of an illness or injury. Sequelae can appear early in the development of disease or weeks to months later and are a result of the initial injury or illness.
Viral encephalitis can occur either as a direct effect of an acute infection, or as one of the sequelae of a latent infection. The majority of viral cases of encephalitis have an unknown cause; however, the most common identifiable cause of viral encephalitis is from herpes simplex infection. [ 12 ]
In accordance with WHO, perinatal asphyxia is characterised by: profound metabolic acidosis, with a pH less than 7.20 on umbilical cord arterial blood sample, persistence of an Apgar score of 3 at the 5th minute, clinical neurologic sequelae in the immediate neonatal period, or evidence of multiorgan system dysfunction in the immediate neonatal ...