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Natamycin has been used for decades in the food industry as a hurdle to fungal outgrowth in dairy products and other foods. Potential advantages for the usage of natamycin might include the replacement of traditional chemical preservatives, a neutral flavor impact, and less dependence on pH for efficacy, as is common with chemical preservatives.
Netarsudil, sold under the brand name Rhopressa among others, is a medication for the treatment of glaucoma. [1] [2] [3] In the United States, in December 2017, the Food and Drug Administration (FDA) approved a 0.02% ophthalmic solution for the lowering of elevated intraocular pressure in people with open-angle glaucoma or ocular hypertension.
[5] [4] It is used as an eye drop. [4] Effects generally occur within two hours. [4] Common side effects include red eyes, blurry vision, eye pain, dry eyes, and change in color of the eyes. [4] [5] Other significant side effects may include cataracts. [5] Use during pregnancy or breastfeeding is generally not recommended. [5]
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Preservative-free eye drops are found in single vials. However, single unit-dose artificial tears without preservatives are more expensive than bottled artificial tears with preservatives. [9] Some patients confuse over the counter drops that contain tetrahydrozoline (i.e. Visine®), a vasoconstrictor, with artificial tears. [11]
Common side effects include red eyes, dry eyes, change in color of the eyes, blurry vision, and cataracts. [ 5 ] [ 6 ] [ 4 ] Use during pregnancy or breastfeeding is generally not recommended. [ 1 ] [ 6 ] [ 4 ] It is a prostaglandin analog and works by increasing the outflow of aqueous fluid from the eyes.
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[5] [12] To keep the specific drug in the therapeutic window using eye drops the topical must be applied approximately every 30 minutes in order to be fully effective. [ 5 ] [ 12 ] Having to apply eye drops every 30 minutes would be nearly impossible for anyone and is not the ideal mechanism by which to deliver such drugs to the eye.
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