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2. GLP-1 receptor agonist - Wikipedia

   en.wikipedia.org/wiki/GLP-1_receptor_agonist

   Native GLP-1 is a peptide hormone with a half-life of 2 minutes because it is rapidly cleared by the enzyme dipeptidyl peptidase-4. [27] As a result, different GLP-1 agonist drugs are modified in various ways to extend the half-life, resulting in drugs that can be dosed multiple times per day, daily, weekly, or even less often. [27]

3. Glucagon-like peptide-1 - Wikipedia

   en.wikipedia.org/wiki/Glucagon-like_peptide-1

   The discovery of GLP-1's extremely short half-life meant that it was impossible to develop into a drug. [35] [36] This caused diabetes research to shift towards other therapeutic options such as targeting the GLP-1 receptor, which then led to the development of GLP-1 receptor agonists. [35] [36]

4. Glucagon-like peptide-1 receptor - Wikipedia

   en.wikipedia.org/wiki/Glucagon-like_peptide-1...

   Different GLP-1 receptor agonists go through inactivation by dipeptidyl peptidase-4 (DPP-4) enzymes (The clinical use of GLP-1 is hampered by its short-half life in the circulation (1-2 min), because of its proteolytic degradation by the enzymes dipeptidyl peptidase-4 (DPP-4) and neutral endopeptidase).

5. Could Eating More Of This Macronutrient Be A Natural ... - AOL

   www.aol.com/lifestyle/could-eating-more...

   GLP-1 receptor agonists, like Ozempic and Wegovy, mimic GLP-1, ... Meanwhile, semaglutide (which is the generic name for Ozempic) has a half-life of 165 hours. Meaning, it will take nearly a week ...

6. What Are GLP-1 Medications & Who Should Use Them? Here ... - AOL

   www.aol.com/glp-1-medications-them-heres...

   GLP-1 agonists are a class of medications that mimic the action of the hormone GLP-1 (glucagon-like peptide-1), which is involved in insulin production and appetite regulation. “GLP-1 stands for ...

7. GLP-1 Diet Plan: What It Is & How to Get Started - AOL

   www.aol.com/glp-1-diet-plan-started-125800192.html

   GLP-1 medications — that’s glucagon-like peptide-1 receptor agonists — are prescribed alongside diet and exercise to help people lose weight or manage type 2 diabetes. But there isn’t an ...