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Here, a top doctor discusses treatments and side effects. ... Dr. Mandel: There are about 170 clinical studies on ketamine therapy for depression and other mental health conditions. The results ...
The use of ketamine as an antidepressant has mainly been studied for the treatment of treatment-resistant depression(TRD). Single-dose use has been found to have noticeable and rapid anti-depressive effects that tend to last up to a week, accompanied by acute side-effects that resolve spontaneously. [21]
Using ketamine for depression. Over the last 20 years, ... However, eight participants reported severe side effects, including severe depression, severe headache, and chest pain.
The mechanism of action of ketamine in alleviating depression is not well understood and is an area of active investigation. Due to the hypothesis that NMDA receptor antagonism underlies the antidepressant effects of ketamine, esketamine was developed as an antidepressant. [11]
Ketamine has been demonstrated to produce lasting antidepressant effects after administration in a clinical setting. In 2019, esketamine, an NMDA antagonist enantiomer of ketamine, was approved for use as an antidepressant in the United States. [17] In 2022, Auvelity was approved by the FDA for the treatment of depression.
Since depression comes in many forms, treating this mental health condition isn’t a one-size-fits-all approach. With a wide variety of treatment methods, it can take time to find the one that ...
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