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“This means [there are] elevated levels of melatonin at night and low levels during the day. This is how melatonin helps regulate our circadian rhythm, which is our biological 24-hour clock ...
The popular sleep aid can have side effects.
Melatonin supplements for sleep come with side effects and their use may raise safety concerns, experts say. There's little evidence they help with insomnia.
Specifically, taking exogenous melatonin shortly after a meal is correlated with impaired glucose tolerance. Therefore, Rubio-Sastre and colleagues recommend waiting at least 2 hours after the last meal before taking a melatonin supplement. [48] Melatonin can cause nausea, next-day grogginess, and irritability. [49]
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Melatonin can suppress libido by inhibiting secretion of luteinizing hormone and follicle-stimulating hormone from the anterior pituitary gland, especially in mammals that have a breeding season when daylight hours are long. The reproduction of long-day breeders is repressed by melatonin and the reproduction of short-day breeders is stimulated ...
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