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The glucose tolerance test was first described in 1923 by Jerome W. Conn. [4]The test was based on the previous work in 1913 by A. T. B. Jacobson in determining that carbohydrate ingestion results in blood glucose fluctuations, [5] and the premise (named the Staub-Traugott Phenomenon after its first observers H. Staub in 1921 and K. Traugott in 1922) that a normal patient fed glucose will ...
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The World Health Organization definition of diabetes (both type 1 and type 2) is for a single raised glucose reading with symptoms, otherwise raised values on two occasions, of either: [65] fasting plasma glucose ≥ 7.0 mmol/L (126 mg/dL) or. glucose tolerance test with two hours after the oral dose a plasma glucose ≥ 11.1 mmol/L (200 mg/dL)
Prediabetes is a component of metabolic syndrome and is characterized by elevated blood sugar levels that fall below the threshold to diagnose diabetes mellitus.It usually does not cause symptoms but people with prediabetes often have obesity (especially abdominal or visceral obesity), dyslipidemia with high triglycerides and/or low HDL cholesterol, and hypertension. [1]
Hepatocyte growth factor (HGF) is a mitogen and insulin tropic agent for the β cell. Inadequate β-cell mass can lead to insulin insufficiency and diabetes. During times of prolonged metabolic demand for insulin, the endocrine pancreas can respond by increasing β-cell mass, both by increasing cell size and by changing the balance between β ...
Based on an oral glucose tolerance test a disposition index can be calculated with D I F S O G T = I G I ⋅ I S I c o m p o s i t e {\displaystyle {DI}_{FSOGT}=IGI\cdot ISI_{composite}} from the insulinogenic index ( IGI ) and the insulin sensitivity index ( ISI composite ).
28999 66277 Ensembl ENSG00000163884 ENSMUSG00000030087 UniProt Q9UIH9 Q9EPW2 RefSeq (mRNA) NM_014079 NM_023184 NM_001355668 RefSeq (protein) NP_054798 NP_075673 NP_001342597 Location (UCSC) Chr 3: 126.34 – 126.36 Mb Chr 6: 90.44 – 90.45 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Krüppel-like factor 15 is a protein that in humans is encoded by the KLF15 gene in the Krüppel ...