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Given the high numbers of individuals diagnosed with schizophrenia (nearly 1% of modern-day populations), it is unlikely that the disorder has arisen solely from random mutations. [2] Instead it is believed that, despite its maladaptive nature, schizophrenia has been either selected for throughout the years or exists as a selective by-product.
Instead of viewing schizophrenia as a by-product of brain evolution, one model presents schizophrenia to be one extreme of a sexually selected fitness indicator. [26] This model hypothesizes schizophrenia to be a side effect in sexual selection for certain traits. Sexual selection concerns the mating choices of humans and other animals.
The cognitive model of abnormality is one of the dominant forces in academic psychology beginning in the 1970s and its appeal is partly attributed to the way it emphasizes the evaluation of internal mental processes such as perception, attention, memory, and problem-solving. The process allows psychologists to explain the development of mental ...
The result means that, of these, 21 will not be identified as having schizophrenia by use of FRS (43% of 48). Then, of the 52 people really without schizophrenia, 10 may be incorrectly diagnosed with schizophrenia by the FRS. Diagnosis of schizophrenia from other types of psychosis Sensitivity 58.0 (50.3, 65.3) Specificity 74.7 (85.2, 82.3)
Biological psychiatry or biopsychiatry is an approach to psychiatry that aims to understand mental disorder in terms of the biological function of the nervous system.It is interdisciplinary in its approach and draws on sciences such as neuroscience, psychopharmacology, biochemistry, genetics, epigenetics and physiology to investigate the biological bases of behavior and psychopathology.
The glutamate hypothesis of schizophrenia models the subset of pathologic mechanisms of schizophrenia linked to glutamatergic signaling. The hypothesis was initially based on a set of clinical, neuropathological, and, later, genetic findings pointing at a hypofunction of glutamatergic signaling via NMDA receptors .
The causes of schizophrenia that underlie the development of schizophrenia, a psychiatric disorder, are complex and not clearly understood.A number of hypotheses including the dopamine hypothesis, and the glutamate hypothesis have been put forward in an attempt to explain the link between altered brain function and the symptoms and development of schizophrenia.
Schizophrenia is a debilitating and often misunderstood disorder that affects up to 1% of the world's population. [1] Although schizophrenia is a heavily studied disorder, it has remained largely impervious to scientific understanding; epigenetics offers a new avenue for research, understanding, and treatment.
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