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Bioidentical hormone replacement therapy (BHRT), also known as bioidentical hormone therapy (BHT) or natural hormone therapy, is the use of hormones that are identical on a molecular level with endogenous hormones in hormone replacement therapy. [1]
The Wiley Protocol is a form of bioidentical hormone replacement therapy (BHRT) devised and advocated by author T. S. Wiley.The protocol claims to relieve the symptoms of menopause but is also promoted as increasing overall health through the recreation of a pre-menopausal woman's monthly hormonal cycle using rhythmic doses of hormones standardized to a uniform purity.
Examples of progestogens include natural or bioidentical progesterone as well as progestins such as medroxyprogesterone acetate and norethisterone. [1] Side effects of progestogens include menstrual irregularities, headaches, nausea, breast tenderness, mood changes, acne, increased hair growth, and changes in liver protein production among others.
[7] [2] [3] Because of this, it is considered to be a natural and bioidentical form of testosterone. [14] Testosterone cypionate was introduced for medical use in 1951. [15] [16] Along with testosterone enanthate, testosterone undecanoate, and testosterone propionate, it is one of the most commonly used testosterone esters.
[9] [8] Because of this, it is considered to be a natural and bioidentical form of estrogen. [9] [10] Estradiol acetate was introduced for medical use in 2001. [11] It is available in the United States and the United Kingdom. [11] [3] The formulation for use by mouth has been discontinued in the United States. [12]
HDE and pseudopregnancy have been used in medicine for a number of hormone-dependent indications, such as breast cancer, prostate cancer, and endometriosis, among others. [1] [7] [2] Both natural or bioidentical estrogens and synthetic estrogens have been used and both oral and parenteral routes may be used. [8] [9]
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