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Research in the 1960s proved that female animals permitted to reach sexual maturity prior to being spayed were susceptible to a higher risk of mammary cancer than those animals spayed prior to their first cycle. As a result, the recommendation was revised to perform surgeries just prior to the average anticipated age for the first cycle, 4 to 6 ...
Female dogs who are not spayed or who are spayed later than the first heat cycle are more likely to develop mammary tumors. Dogs have an overall reported incidence of mammary tumors of 3.4 percent. Dogs spayed before their first heat have 0.5 percent of this risk, and dogs spayed after just one heat cycle have 8 percent of this risk. [1]
The incidence of mammary tumours in un-spayed female dogs is 71% (of which approximately 50% will be malignant and 50% will be benign), but if a dog is spayed before its first heat cycle, the risk of developing a mammary tumour is reduced to 0.35%—a 99.5% reduction.
It is not essential for a female dog to either experience a heat cycle or have puppies before spaying, and likewise, a male dog does not need the experience of mating before neutering. Female cats and dogs are seven times more likely to develop mammary tumors if they are not spayed before their first heat cycle. [77]
Dogs shown in the conformation ring are not allowed to be either neutered or spayed. It disqualifies them from being shown as they must be intact and unaltered. [citation needed] Female cats and dogs are seven times more likely to develop mammary tumors if they are not spayed before their first heat cycle. [48]
Pyometra is a result of hormonal and structural changes in the uterus lining. This can happen at any age, regardless of how many heat cycles have occurred or previous pregnancies (or lack thereof), although it becomes more common as the dog gets older. The main risk period for a female is for eight weeks after her peak standing heat has ended. [2]
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Neutering male cats makes them less subject to testicular cancer, FeLV, and FIV. Spaying female cats lowers the risk of mammary, ovarian, and uterine cancer, as it prevents them from going into heat. Female cats should be spayed before their first heat, as each cycle of heat creates a greater risk of mammary cancer.