Search results
Results from the WOW.Com Content Network
However, using patient-reported outcomes does not solve the problem of small differences being statistically significant but possibly clinically irrelevant. [6] In order to study clinical importance, the concept of minimal clinically important difference (MCID) was proposed by Jaeschke et al. in 1989. [7]
In broad usage, the "practical clinical significance" answers the question, how effective is the intervention or treatment, or how much change does the treatment cause. In terms of testing clinical treatments, practical significance optimally yields quantified information about the importance of a finding, using metrics such as effect size, number needed to treat (NNT), and preventive fraction ...
In some individuals, clinically insignificant antibodies may cause in vitro agglutination of platelets. As a result of platelet clumping, platelet counts reported by automated counters may be much lower than the actual count in the blood because these devices cannot differentiate platelet clumps from individual cells.
As of 2020, there continues to be limited involvement from federal agencies to regulate the clinical validity (accuracy) and utility (risks and benefits) of genetic testing. [ 11 ] [ 12 ] [ 13 ] Variant interpretation and classification is notably subjective, as laboratories developed their own criteria prior to the ACMG-AMP guidelines.
Increasingly, it is becoming apparent that mass screening hasn’t achieved what many hoped it would, and for too many Americans, it does more harm than good when applied to early-stage cancers.
This page provides a list of medical abbreviations that start with the letter B.
The term significance does not imply importance here, and the term statistical significance is not the same as research significance, theoretical significance, or practical significance. [ 1 ] [ 2 ] [ 18 ] [ 19 ] For example, the term clinical significance refers to the practical importance of a treatment effect.
To a casual observer, this skirmish on the internet of wellness—a place where dubious health claims abound—over a celebrity-endorsed dietary supplement might seem insignificant or even suspect.