Search results
Results from the WOW.Com Content Network
Arsenic trioxide binds to the cysteine at position 179 of IKKβ, thus preventing the release of NF-κB. [35] The absence of this protein in the cytoplasm allows for the induction of apoptosis via the extrinsic pathway and activates caspases 3 and 8.
Arsenic trioxide is indicated in combination with tretinoin for treatment of adults with newly-diagnosed low-risk acute promyelocytic leukemia whose acute promyelocytic leukemia is characterized by the presence of the t(15;17) translocation or PML/RAR-alpha gene expression; and for induction of remission and consolidation in patients with acute promyelocytic leukemia who are refractory to, or ...
The first breakthrough in the detection of arsenic poisoning was in 1775 when Carl Wilhelm Scheele discovered a way to change arsenic trioxide to garlic-smelling arsine gas (AsH 3), by treating it with nitric acid (HNO 3) and combining it with zinc. [3] As 2 O 3 + 6 Zn + 12 HNO 3 → 2 AsH 3 + 6 Zn(NO 3) 2 + 3 H 2 O
Arsenic trioxide powder.. Compounds of arsenic resemble in some respects those of phosphorus which occupies the same group (column) of the periodic table.The most common oxidation states for arsenic are: −3 in the arsenides, which are alloy-like intermetallic compounds, +3 in the arsenites, and +5 in the arsenates and most organoarsenic compounds.
Arsenic oxide may refer to any of the following: Arsenic dioxide, As 2 O 4; Arsenic trioxide, As 2 O 3; Arsenic pentoxide, As 2 O 5 This page was last edited on 2 ...
It burns in oxygen to form arsenic trioxide and arsenic pentoxide, which have the same structure as the more well-known phosphorus compounds, and in fluorine to give arsenic pentafluoride. [31] Arsenic makes arsenic acid with concentrated nitric acid , arsenous acid with dilute nitric acid, and arsenic trioxide with concentrated sulfuric acid ...
Arsenic is a moderately abundant element in Earth's crust, and although many arsenic compounds are often considered highly toxic to most life, a wide variety of organoarsenic compounds are produced biologically and various organic and inorganic arsenic compounds are metabolized by numerous organisms.
Reactions attributed to aqueous arsenic trioxide are due to arsenous acid and its conjugate bases. Like arsenic trioxide, arsenous acid is sometimes amphoteric. For example, it reacts with hydrochloric, hydrobromic, and hydroiodic acids to produce arsenic trichloride, tribromide, and triiodide. As(OH) 3 + 3 HCl ⇌ AsCl 3 + 3 H 2 O