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Under the trade name Mircera, Roche Pharmaceuticals received approval from the U.S. Food and Drug Administration (FDA) in January 2008 to market a continuous erythropoiesis receptor activator (methoxy polyethylene glycol-epoetin beta) for the treatment of anemia in patients with chronic kidney disease, including in those undergoing dialysis.
8851 12569 Ensembl ENSG00000176749 ENSMUSG00000048895 UniProt Q15078 P61809 RefSeq (mRNA) NM_003885 NM_009871 RefSeq (protein) NP_003876 NP_034001 Location (UCSC) Chr 17: 32.49 – 32.49 Mb Chr 11: 80.37 – 80.37 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cyclin-dependent kinase 5 activator 1 is an enzyme that in humans is encoded by the CDK5R1 gene. Function The protein ...
A transcriptional activator is a protein (transcription factor) that increases transcription of a gene or set of genes. [1] Activators are considered to have positive control over gene expression, as they function to promote gene transcription and, in some cases, are required for the transcription of genes to occur.
[1] [2] CRP then activates transcription through direct protein–protein interactions with RNA polymerase. [1] [2] The genes regulated by CRP are mostly involved in energy metabolism, such as galactose, citrate, or the PEP group translocation system. [3] [4] In Escherichia coli, CRP can regulate the transcription of more than 100 genes. [5]
For radiolabeling, the pH of the 68 Ga containing generator eluate has to be raised from its initial value (depending on HCl concentration, pH 1–1.5) to pH 2–3.5 [11] using suitable buffers, such as sodium acetate.
12568 Ensembl ENSG00000164885 ENSMUSG00000028969 UniProt Q00535 P49615 RefSeq (mRNA) NM_001164410 NM_004935 NM_007668 RefSeq (protein) NP_001157882 NP_004926 NP_031694 Location (UCSC) Chr 7: 151.05 – 151.06 Mb Chr 5: 24.62 – 24.63 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cyclin-dependent kinase 5 is a protein, and more specifically an enzyme, that is encoded by the Cdk5 ...
6772 20846 Ensembl ENSG00000115415 ENSMUSG00000026104 UniProt P42224 P42225 RefSeq (mRNA) NM_007315 NM_139266 NM_001205313 NM_001205314 NM_009283 NM_001357627 RefSeq (protein) NP_009330 NP_644671 n/a Location (UCSC) Chr 2: 190.91 – 191.02 Mb Chr 1: 52.16 – 52.2 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Signal transducer and activator of transcription 1 (STAT1) is a ...
Signal transducer and activator of transcription 5 (STAT5) refers to two highly related proteins, STAT5A and STAT5B, which are part of the seven-membered STAT family of proteins. Though STAT5A and STAT5B are encoded by separate genes , the proteins are 90% identical at the amino acid level. [ 1 ]