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8851 12569 Ensembl ENSG00000176749 ENSMUSG00000048895 UniProt Q15078 P61809 RefSeq (mRNA) NM_003885 NM_009871 RefSeq (protein) NP_003876 NP_034001 Location (UCSC) Chr 17: 32.49 – 32.49 Mb Chr 11: 80.37 – 80.37 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cyclin-dependent kinase 5 activator 1 is an enzyme that in humans is encoded by the CDK5R1 gene. Function The protein ...
Under the trade name Mircera, Roche Pharmaceuticals received approval from the U.S. Food and Drug Administration (FDA) in January 2008 to market a continuous erythropoiesis receptor activator (methoxy polyethylene glycol-epoetin beta) for the treatment of anemia in patients with chronic kidney disease, including in those undergoing dialysis.
A transcriptional activator is a protein (transcription factor) that increases transcription of a gene or set of genes. [1] Activators are considered to have positive control over gene expression, as they function to promote gene transcription and, in some cases, are required for the transcription of genes to occur.
[1] [2] CRP then activates transcription through direct protein–protein interactions with RNA polymerase. [1] [2] The genes regulated by CRP are mostly involved in energy metabolism, such as galactose, citrate, or the PEP group translocation system. [3] [4] In Escherichia coli, CRP can regulate the transcription of more than 100 genes. [5]
12568 Ensembl ENSG00000164885 ENSMUSG00000028969 UniProt Q00535 P49615 RefSeq (mRNA) NM_001164410 NM_004935 NM_007668 RefSeq (protein) NP_001157882 NP_004926 NP_031694 Location (UCSC) Chr 7: 151.05 – 151.06 Mb Chr 5: 24.62 – 24.63 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cyclin-dependent kinase 5 is a protein, and more specifically an enzyme, that is encoded by the Cdk5 ...
In the human genome, STAT6 protein is encoded by the STAT6 gene, located on the chromosome 12q13.3-q14.1. [6] The gene encompasses over 19 kb and consists of 23 exons . [ 7 ] STAT6 shares structural similarity with the other STAT proteins and is composed of the N-terminal domain , DNA binding domain , SH3- like domain, SH2 domain and ...
6772 20846 Ensembl ENSG00000115415 ENSMUSG00000026104 UniProt P42224 P42225 RefSeq (mRNA) NM_007315 NM_139266 NM_001205313 NM_001205314 NM_009283 NM_001357627 RefSeq (protein) NP_009330 NP_644671 n/a Location (UCSC) Chr 2: 190.91 – 191.02 Mb Chr 1: 52.16 – 52.2 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Signal transducer and activator of transcription 1 (STAT1) is a ...
Signal transducer and activator of transcription 5 (STAT5) refers to two highly related proteins, STAT5A and STAT5B, which are part of the seven-membered STAT family of proteins. Though STAT5A and STAT5B are encoded by separate genes , the proteins are 90% identical at the amino acid level. [ 1 ]