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A shin splint, also known as medial tibial stress syndrome, is pain along the inside edge of the shinbone due to inflammation of tissue in the area. [1] Generally this is between the middle of the lower leg and the ankle. [2] The pain may be dull or sharp, and is generally brought on by high-impact exercise that overloads the tibia. [1]
Cell damage (also known as cell injury) is a variety of changes of stress that a cell suffers due to external as well as internal environmental changes. Amongst other causes, this can be due to physical, chemical, infectious, biological, nutritional or immunological factors. Cell damage can be reversible or irreversible.
Ischemic cell death, or oncosis, is a form of accidental cell death.The process is characterized by an ATP depletion within the cell leading to impairment of ionic pumps, cell swelling, clearing of the cytosol, dilation of the endoplasmic reticulum and golgi apparatus, mitochondrial condensation, chromatin clumping, and cytoplasmic bleb formation. [1]
Splints usually cause mild lameness (a grade of 1–2 out of 5). The injured area is hot, painful, and inflamed with a small bony swelling. However, splints do not always cause lameness, especially once "cold". More severe lameness is sometimes associated with a fractured splint bone, or soft tissue injury adjacent to the splints.
This disruption, in turn, may prompt the improper destruction or removal of a cell with damaged elements as well as other related issues. These issues include cell accumulation and uncontrolled cell growth, which results in the formation of cancerous and abnormal tissue masses known as tumors. Therefore, being able to observe or identify when a ...
By inserting a micropipette into a cell, the cell can be aspirated rapidly until destruction of cortex-membrane bonds causes blebbing. [11] Breakage of cortex-membrane bonds has also been caused by laser ablation and injection of an actin depolymerizing drug, which in both cases eventually led to blebbing of the cell membrane. [11]
The basic unit of the Reactome database is a reaction; reactions are then grouped into causal chains to form pathways [115] The Reactome data model allows us to represent many diverse processes in the human system, including the pathways of intermediary metabolism, regulatory pathways, and signal transduction, and high-level processes, such as ...
It can occur in adults as the result of injuries and other similar conditions that cause the ligaments to weaken, such as connective tissue disease or pregnancy. [2] Wandering spleen (splenoptosis) predisposes the spleen to complications such as torsion, splenic infarction, pancreatic necrosis and rarely pseudocyst formation.