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Drugs used in diabetes treat types of diabetes mellitus by decreasing glucose levels in the blood. With the exception of insulin , most GLP-1 receptor agonists ( liraglutide , exenatide , and others), and pramlintide , all diabetes medications are administered orally and are thus called oral hypoglycemic agents or oral antihyperglycemic agents.
Additionally, some medications that reduce blood sugars such as insulin may initially cause weight gain due to the increased conversion of blood sugar to stored forms such as fat. [29] Therefore, in patients with diabetes, providers may try other medications that lower blood sugar but not cause as much weight gain. [29]
By reducing glucose blood circulation, gliflozins cause less stimulation of endogenous insulin secretion or lower dose of exogenous insulin that results in diabetic ketoacidosis. They can specifically cause euglycemic DKA (euDKA, DKA where the blood sugar is not elevated) because of the renal tubular absorption of ketone bodies. [13]
Interest surrounding glucagon-like peptide 1 agonists , a class of type 2 diabetes drugs that help blood sugar management and may lead to weight loss, continues to grow. With more medications ...
And, a 2022 study published in JAMA Open Network found that a low-carb diet improved blood sugar levels for people with high A1C who weren’t taking glucose-lowering medications ...
In those already taking sulphonylureas, there is an increased risk of low blood sugar when taking a medicine in the DPP-4 drug class. [19] Adverse effects include nasopharyngitis, headache, nausea, heart failure, hypersensitivity and skin reactions.
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