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Avascular necrosis (AVN), also called osteonecrosis or bone infarction, is death of bone tissue due to interruption of the blood supply. [1] Early on, there may be no symptoms. [ 1 ] Gradually joint pain may develop, which may limit the person's ability to move. [ 1 ]
Dieterich's disease, also known as avascular necrosis of the metacarpal head, [1] is an extremely rare condition characterized by temporary or permanent loss of blood supply to the metacarpal head of the metacarpal bone, resulting in loss of bone tissue.
Specifically, Kienböck's disease is another name for avascular necrosis [2] (death and fracture of bone tissue due to interruption of blood supply) with fragmentation and collapse of the lunate. This has classically been attributed to arterial disruption, but may also occur after events that produce venous congestion with elevated interosseous ...
The major tissues affected are nerves and muscles, where irreversible damage starts to occur after 4–6 hours of cessation of blood supply. [4] Skeletal muscle, the major tissue affected, is still relatively resistant to infarction compared to the heart and brain because its ability to rely on anaerobic metabolism by glycogen stored in the cells may supply the muscle tissue long enough for ...
A major presentation is painful thigh or leg swelling. [11] Bone: Infarction of bone results in avascular necrosis. Without blood, the bone tissue dies and the bone collapses. [12] If avascular necrosis involves the bones of a joint, it often leads to destruction of the joint articular surfaces (see osteochondritis dissecans).
The condition is usually characterized by a sudden onset of knee pain, worse at night, or during weight-bearing such as standing or running. Nevertheless, it can also occur during rest or without any weight-bearing. About 94% of the cases affect the medial condyle of the femur. This is because the blood supply for the medial condyle is less ...
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The pathology of avascular necrosis followed by revascularization and bony remodeling of the femoral head in the dog certainly suggests a vascular etiology, though the cause of the condition is not completely understood. [40] Hip pain is usually seen by the age of 6 to 8 months. [41] The disease is bilateral in 12–16% of cases. [42]