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  2. Spironolactone - Wikipedia

    en.wikipedia.org/wiki/Spironolactone

    In those with liver or kidney problems, extra care should be taken. [4] Spironolactone has not been well studied in pregnancy and should not be used to treat high blood pressure of pregnancy. [3] It is also a steroid that blocks the effects of the hormones aldosterone and, to a lesser degree, testosterone, causing some estrogen-like effects.

  3. Management of prostate cancer - Wikipedia

    en.wikipedia.org/wiki/Management_of_prostate_cancer

    The relative risk reduction was 57.7%. For patients at similar risk to those in this study (35.5% of patients had positive surgical margins following RRP), this leads to an absolute risk reduction of 20.5%. 4.9 patients must be treated for one to benefit (number needed to treat = 4.9).

  4. Furosemide - Wikipedia

    en.wikipedia.org/wiki/Furosemide

    Furosemide, sold under the brand name Lasix among others, is a loop diuretic medication used to treat edema due to heart failure, liver scarring, or kidney disease. [4] Furosemide may also be used for the treatment of high blood pressure . [ 4 ]

  5. Chemotherapy - Wikipedia

    en.wikipedia.org/wiki/Chemotherapy

    Chemotherapy does not always work, and even when it is useful, it may not completely destroy the cancer. People frequently fail to understand its limitations. In one study of people who had been newly diagnosed with incurable, stage 4 cancer , more than two-thirds of people with lung cancer and more than four-fifths of people with colorectal ...

  6. Loop diuretic - Wikipedia

    en.wikipedia.org/wiki/Loop_diuretic

    A bolus intravenous dose of 10 or 20 mg of furosemide can be administered and then followed by intravenous bolus of 2 or 3% hypertonic saline to increase the serum sodium level. [12] Pulmonary edema - Slow intravenous bolus dose of 40 to 80 mg furosemide at 4 mg per minute is indicated for patients with fluid overload and pulmonary edema. Such ...

  7. Diuretic - Wikipedia

    en.wikipedia.org/wiki/Diuretic

    They work primarily by expanding extracellular fluid and plasma volume, therefore increasing blood flow to the kidney, particularly the peritubular capillaries. This reduces medullary osmolality and thus impairs the concentration of urine in the loop of Henle (which usually uses the high osmotic and solute gradient to transport solutes and water).

  8. CDK inhibitor - Wikipedia

    en.wikipedia.org/wiki/CDK_inhibitor

    Another remaining question surrounding CDK inhibitors as a therapy is if certain cancers will evade or be resistant to treatment. One study showed that 20% of the patients being treated for metastatic ER+ HER2-breast cancer did not respond at all to treatment with a CDK4/6 inhibitor due to preexisting mutations allowing the cancer cells to continue proliferating despite treatment with the drug ...

  9. Active surveillance of prostate cancer - Wikipedia

    en.wikipedia.org/wiki/Active_surveillance_of...

    At 12 years, a subset of men with a PSA above 10 ng/ml and those with intermediate to high risk disease had a reduction in prostate cancer death with surgery as compared to watchful waiting. [ 10 ] The findings from the SPGS-4 and PIVOT should inform practice for the older man with low risk disease, especially those with associated ...

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