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Involucrin is a highly reactive, soluble, transglutaminase substrate protein present in keratinocytes of epidermis and other stratified squamous epithelia. [7] [8] It first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase thus helping in the formation of an insoluble envelope beneath the plasma membrane functioning as a glutamyl donor ...
Micrograph of keratinocytes, basal cells and melanocytes in the epidermis Keratinocytes (stained green) in the skin of a mouse. Keratinocytes are the primary type of cell found in the epidermis, the outermost layer of the skin. In humans, they constitute 90% of epidermal skin cells. [1]
A deficiency is associated with ichthyosis lamellaris. [11] Epidermal transglutaminase is the autoantigen, in humans, of dermatitis herpetiformis.. A study on the mutation of keratinocyte transglutaminase (TGK) came to conclude that those affected with ichthyosis lamellaris, present a substantial deficit in keratinocyte transglutaminase activity. [8]
The integumentary system is the set of organs forming the outermost layer of an animal's body. It comprises the skin and its appendages, which act as a physical barrier between the external environment and the internal environment that it serves to protect and maintain the body of the animal. Mainly it is the body's outer skin.
Tissue culture commonly refers to the culture of animal cells and tissues, with the more specific term plant tissue culture being used for plants. The term "tissue culture" was coined by American pathologist Montrose Thomas Burrows. [1] This is possible only in certain conditions. It also requires more attention.
Loss of this function contributes to the massive fluid loss in burns. Aesthetics and communication : others see our skin and can assess our mood, physical state and attractiveness. Storage and synthesis : acts as a storage centre for lipids and water, as well as a means of synthesis of vitamin D by action of UV on certain parts of the skin.
Fish and frog melanophores are cells that can change colour by dispersing or aggregating pigment-containing melanosomes. A melanosome is an organelle found in animal cells and is the site for synthesis, storage and transport of melanin , the most common light-absorbing pigment found in the animal kingdom .
A wheeled buffalo figurine—probably a children's toy—from Magna Graecia in archaic Greece [1]. Several organisms are capable of rolling locomotion. However, true wheels and propellers—despite their utility in human vehicles—do not play a significant role in the movement of living things (with the exception of the corkscrew-like flagella of many prokaryotes).