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Other causes of peptic ulcer disease include gastric ischaemia, drugs, metabolic disturbances, cytomegalovirus (CMV), upper abdominal radiotherapy, Crohn's disease, and vasculitis. [15] Gastrinomas (Zollinger–Ellison syndrome), or rare gastrin-secreting tumors, also cause multiple and difficult-to-heal ulcers. [34]
This is a timeline of the events relating to the discovery that peptic ulcer disease and some cancers are caused by H. pylori. In 2005, Barry Marshall and Robin Warren were awarded the Nobel Prize in Physiology or Medicine for their discovery that peptic ulcer disease (PUD) was primarily caused by Helicobacter pylori , a bacterium with affinity ...
Other conditions with similar symptoms include inflammation of the pancreas, gallbladder problems, and peptic ulcer disease. [2] Prevention is by avoiding things that cause the disease. [4] [examples needed] Treatment includes medications such as antacids, H2 blockers, or proton pump inhibitors. [1]
Eradication of H. pylori is recommended to treat the infection, including when advanced to peptic ulcer disease. The recommendations for first-line treatment is a quadruple therapy consisting of a proton-pump inhibitor, amoxicillin, clarithromycin, and metronidazole. Prior to treatment, testing is recommended to identify any pre-existing ...
Gastrinoma in the early stages will have signs and symptoms of indigestion [3] or similar to irritable bowel disease (IBD) such as: Hypergastrinemia [3] Refractory or recurrent peptic ulcers involving duodenum [3] Chronic diarrhea [7] [2] [3] Generalized cancer symptoms; Abdominal pain [3] Gastrointestinal bleeding [3] Obstruction of intestine [8]
Acid peptic diseases, such as peptic ulcers, Zollinger-Ellison syndrome, and gastroesophageal reflux disease, are caused by distinct but overlapping pathogenic mechanisms involving acid effects on mucosal defense. Acid reflux damages the esophageal mucosa and may also cause laryngeal tissue injury, leading to the development of pulmonary ...
Peptic ulcer disease; Infections, such as tuberculosis; and infiltrative diseases, such as amyloidosis. A rare cause of gastric outlet obstruction is blockage with a gallstone, also termed "Bouveret syndrome" or "Bouveret's syndrome". In children, congenital pyloric stenosis / congenital hypertrophic pyloric stenosis may be a cause.
Zollinger–Ellison syndrome (Z-E syndrome) is a rare disease in which tumors cause the stomach to produce too much acid, resulting in peptic ulcers. Symptoms include abdominal pain and diarrhea. The syndrome is caused by the formation of a gastrinoma, a neuroendocrine tumor that secretes a hormone called gastrin. [2]