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The progestogens are named for their function in maintaining pregnancy (i.e., progestational), although they are also present at other phases of the estrous and menstrual cycles. [ 2 ] [ 3 ] The progestogens are one of three types of sex hormones , the others being estrogens like estradiol and androgens / anabolic steroids like testosterone .
Megestrol acetate is the lead drug of this class for the management of cachexia, and medroxyprogesterone acetate is also used. [ 43 ] [ 44 ] The mechanism of action of the appetite-related effects of these two medications is unknown and may not be related to their progestogenic activity.
The pregnancy category of a medication is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother during pregnancy. It does not include any risks conferred by pharmaceutical agents or their metabolites in breast milk. Every drug has specific information listed in its product literature.
Women should speak to their doctor or healthcare professional before starting or stopping any medications while pregnant. [1] Drugs taken in pregnancy including over-the counter-medications, prescription medications, nutritional supplements, recreational drugs, and illicit drugs may cause harm to the mother or the unborn child.
Ergometrine, also known as ergonovine and sold under the brand names Ergotrate, Ergostat, and Syntometrine among others, is a medication used to cause contractions of the uterus to treat heavy vaginal bleeding after childbirth. [5] [1] It can be used either by mouth, by injection into a muscle, or injection into a vein. [5]
Ergotamine interacts with serotonin, adrenergic, and dopamine receptors. [17] [18] It is an agonist of serotonin receptors including the 5-HT 1 and 5-HT 2 subtypes. [17]Ergotamine is an agonist of the serotonin 5-HT 2B receptor and has been associated with cardiac valvulopathy. [19]
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Fernand Lamaze visited the Soviet Union in the 1950s, and was influenced by birthing techniques which involved breathing and relaxation methods. [3] The Lamaze method gained popularity in the United States after Marjorie Karmel wrote about her experiences in her 1959 book Thank You, Dr. Lamaze, as well as Elisabeth Bing's book Six Practical Lessons for an Easier Childbirth (1960).
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