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Sample size determination or estimation is the act of choosing the number of observations or replicates to include in a statistical sample. The sample size is an important feature of any empirical study in which the goal is to make inferences about a population from a sample.
nQuery is a clinical trial design platform used for the design and monitoring of adaptive, group sequential, and fixed sample size trials. It is most commonly used by biostatisticians to calculate sample size and statistical power for adaptive clinical trial design. nQuery is proprietary software developed and distributed by Statsols.
While at UCLA and Cedars-Sinai during the 1990s, she wrote the program nQuery Sample Size Software (then known as nQuery Advisor). This quickly became widely used to estimate the sample size requirements for pharmaceutical testing and she joined the company Statistical Solutions LLC to commercialize it. [4]
The table lists all possible analyses that the updated G*Power 3.1 can perform for various functions. A priori analyses are one of the most commonly used analyses in research and calculate the needed sample size in order to achieve a sufficient power level and requires inputted values for alpha and effect size.
Fisher's exact test (also Fisher-Irwin test) is a statistical significance test used in the analysis of contingency tables. [1] [2] [3] Although in practice it is employed when sample sizes are small, it is valid for all sample sizes.
Post-hoc analysis of "observed power" is conducted after a study has been completed, and uses the obtained sample size and effect size to determine what the power was in the study, assuming the effect size in the sample is equal to the effect size in the population. Whereas the utility of prospective power analysis in experimental design is ...
Matched or independent study designs may be used. Power, sample size, and the detectable alternative hypothesis are interrelated. The user specifies any two of these three quantities and the program derives the third. A description of each calculation, written in English, is generated and may be copied into the user's documents.
Correction factor versus sample size n.. When the random variable is normally distributed, a minor correction exists to eliminate the bias.To derive the correction, note that for normally distributed X, Cochran's theorem implies that () / has a chi square distribution with degrees of freedom and thus its square root, / has a chi distribution with degrees of freedom.