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Clostridium perfringens alpha toxin (α-toxin) C. perfringens alpha toxin is widely associated with gas gangrene as it is its main virulence factor whilst invading its host. Alpha-toxin causes excessive platelet aggregation which blocks blood vessels and deprives the vital organs of oxygen supply. This creates an acidic, oxygen-deficient ...
Clostridium perfringens is the most common bacterial agent for gas gangrene. [45] Gas gangrene is induced by α-toxin that embeds itself into the plasma membrane of cells and disrupts normal cellular function by altering membrane structure. [8] Some symptoms include blisters, tachycardia, swelling, and jaundice. [45]
Clostridium perfringens can cause of brain abscesses ... In adults the most common source of ... ulcers, bite wound, [38] anaerobic cellulitis and gas gangrene, ...
This toxin has been shown to be the key virulence factor in infection with C. perfringens; the bacterium is unable to cause disease without this toxin. [1] Further, vaccination against the alpha toxin toxoid protects mice against C. perfringens gas gangrene. [2]
Clostridium perfringens causes a wide range of symptoms, from food poisoning to cellulitis, fasciitis, necrotic enteritis and gas gangrene. [16] [17] Clostridium tetani causes tetanus. Several more pathogenic species, that were previously described in Clostridium, have been found to belong to other genera. [6]
Clostridium perfringens: Food poisoning by Clostridium perfringens: Stool test Supportive care No multiple Free-living amebic infection: No Fusobacterium species Fusobacterium infection No usually Clostridium perfringens; other Clostridium species Gas gangrene (Clostridial myonecrosis) No Geotrichum candidum: Geotrichosis: No PRNP
In times of poor surgical practice, post-surgical complications involved anaerobic infection by Clostridium perfringens strains, which can cause gas gangrene in tissues, also giving rise to crepitus. Subcutaneous crepitus (or surgical emphysema) is a crackling sound resulting from subcutaneous emphysema, or air trapped in the subcutaneous tissues.
Welch's research was principally in bacteriology, and he is the discoverer of the organism that causes gas gangrene. It was named Clostridium welchii in recognition of that fact, but now the organism usually is designated as Clostridium perfringens.