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RNA editing was first discovered within the mitochondria of kinetoplastid protozoans, where it has been shown to be extensive. [30] For example, some protein-coding genes encode fewer than 50% of the nucleotides found within the mature, translated mRNA. Other RNA editing events are found in mammals, plants, bacteria and viruses.
Rosalind Elsie Franklin (25 July 1920 – 16 April 1958) [1] was a British chemist and X-ray crystallographer.Her work was central to the understanding of the molecular structures of DNA (deoxyribonucleic acid), RNA (ribonucleic acid), viruses, coal, and graphite. [2]
[197] [198] This system provided the first clear suggestion that DNA carries genetic information. In 1933, while studying virgin sea urchin eggs, Jean Brachet suggested that DNA is found in the cell nucleus and that RNA is present exclusively in the cytoplasm. At the time, "yeast nucleic acid" (RNA) was thought to occur only in plants, while ...
All living cells contain both DNA and RNA (except some cells such as mature red blood cells), while viruses contain either DNA or RNA, but usually not both. [15] The basic component of biological nucleic acids is the nucleotide, each of which contains a pentose sugar (ribose or deoxyribose), a phosphate group, and a nucleobase. [16]
The intervening sequences in the RNA strand are first spliced out so that only the RNA segment left behind after splicing would be translated to polypeptides. [62] 1994: The first breast cancer gene is discovered. BRCA I was discovered by researchers at the King laboratory at UC Berkeley in 1990 but was first cloned in 1994.
Franklin was a physical chemist who made pivotal research in the discovery of the structure of DNA, known as "the most important discovery" in biology. [1] [2] DNA itself had become "life's most famous molecule". [3] While working at the King's College London in 1951, she discovered two types of DNA called A-DNA and B-DNA. Her X-ray images of ...
Norman Simmons (1915–2004), US DNA research pioneer, who donated pure DNA to Rosalind Franklin in the prelude to the double helix discovery; Piotr Słonimski (1922–2009), Polish-Parisian yeast geneticist, pioneer of mitochondrial heredity; William S. Sly (born 1932), US biochemical geneticist, mucopolysaccharidosis type VII (Sly syndrome)
He characterized the different forms of nucleic acid, DNA from RNA, and found that DNA contained adenine, guanine, thymine, cytosine, deoxyribose, and a phosphate group. [1] He was born into a Litvak (Lithuanian Jewish) family as Fishel Aronovich Levin in the town of Žagarė in Lithuania, then part of the Russian Empire, but grew up in St ...