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[8] [9] It was developed as a recombinant protein (rhIL-11) as the drug substance oprelvekin. The human IL-11 gene, consisting of 5 exons and 4 introns, is located on chromosome 19, [6] and encodes a 23 kDa protein. IL-11 is a member of the IL-6-type cytokine family, distinguished based on their use of the common co-receptor gp130.
The interleukin 11 receptor is a type I cytokine receptor, binding interleukin 11. It is a heterodimer composed of an interleukin 11 receptor alpha subunit and an incompletely characterized beta subunit.
Interleukin 11 (IL-11) is a secreted protein that stimulates megakaryocytopoiesis, initially thought to lead to an increased production of platelets (it has since been shown to be redundant to normal platelet formation), as well as activating osteoclasts, inhibiting epithelial cell proliferation and apoptosis, and inhibiting macrophage mediator ...
Interleukin 11 receptor, alpha subunit is a subunit of the interleukin 11 receptor. IL11RA is its human gene. [5] Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which ...
Oprelvekin is recombinant interleukin eleven (IL-11), [1] a thrombopoietic growth factor that directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production.
1. Gigayacht. Sold for: $168 million Roman Abramovich, a Russian billionaire, must have been staring at an empty dock for a while now, because the 168 milly he shelled out for a 400-foot yacht is ...
As per Parade, southern states tend to have lower egg prices in December 2024, with an average of $3.40 per dozen.On the other hand of the spectrum, California saw the highest numbers with a ...
16409 Ensembl ENSG00000169896 ENSMUSG00000030786 UniProt P11215 P05555 RefSeq (mRNA) NM_000632 NM_001145808 NM_001082960 NM_008401 RefSeq (protein) NP_000623 NP_001139280 n/a Location (UCSC) Chr 16: 31.26 – 31.33 Mb Chr 7: 127.66 – 127.72 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Integrin alpha M (ITGAM) is one protein subunit that forms heterodimeric integrin alpha-M beta ...