enow.com Web Search

Search results

1. Results from the WOW.Com Content Network

2. Pharmacodynamics of spironolactone - Wikipedia

   en.wikipedia.org/wiki/Pharmacodynamics_of...

   [28] [16] In addition, the AR antagonism of spironolactone is involved in its feminizing side effects, such as gynecomastia in men. [28] Spironolactone has been found to produce gynecomastia without changes in testosterone or estradiol levels, implicating AR antagonism in this side effect. [30] Gynecomastia is a major known side effect of AR ...

3. Urinary anti-infective agent - Wikipedia

   en.wikipedia.org/wiki/Urinary_anti-infective_agent

   Kidney disease can affect drug elimination, absorption, and distribution in the body, leading to altered serum drug concentrations. This can increase the risk of drug toxicity or suboptimal therapeutic effects. As a result, dosage adjustments are necessary for patients who fail to achieve the desired therapeutic serum drug levels. [27]

4. Spironolactone - Wikipedia

   en.wikipedia.org/wiki/Spironolactone

   Low-dose spironolactone is generally very well tolerated. [63] Even higher doses of spironolactone, such as 100 mg/day, are well tolerated in most individuals. [63] Dose-dependent side effects of spironolactone include menstrual irregularities, breast tenderness, and enlargement, orthostatic hypotension, and hyperkalemia. [63]

5. Trimethoprim/sulfamethoxazole - Wikipedia

   en.wikipedia.org/wiki/Trimethoprim/sulfamethoxazole

   Common side effects include nausea, vomiting, rash, and diarrhea. [2] Severe allergic reactions and Clostridioides difficile infection may occasionally occur. [2] Its use in pregnancy is not recommended. [2] [19] It appears to be safe for use during breastfeeding as long as the baby is healthy. [19]

6. Mineralocorticoid receptor antagonist - Wikipedia

   en.wikipedia.org/wiki/Mineralocorticoid_receptor...

   Eplerenone is a newer drug that was developed as a spironolactone analog with reduced adverse effects. In addition to the y-lactone ring and the substituent on C-7, eplerenone has a 9α,11α-epoxy group. This group is believed to be the reason why eplerenone has a 20-40-fold lower affinity for the mineralocorticoid receptor than spironolactone. [7]

7. Imipenem/cilastatin/relebactam - Wikipedia

   en.wikipedia.org/wiki/Imipenem/cilastatin/relebactam

   Both imipenem and relebactam have renal clearance and a half-life of approximately 1 h. Dose adjustment should be performed in renal impairment. ... Drug Information ...

8. Spirolactone - Wikipedia

   en.wikipedia.org/wiki/Spirolactone

   Spirolactones are a class of functional group in organic chemistry featuring a cyclic ester attached spiro to another ring system. The name is also used to refer to a class of synthetic steroids, called steroid-17α-spirolactones, 17α-spirolactosteroids, or simply 17α-spirolactones, which feature their spirolactone group at the C17α position.

9. β-Lactam antibiotic - Wikipedia

   en.wikipedia.org/wiki/Β-Lactam_antibiotic

   β-Lactam antibiotics are indicated for the prevention and treatment of bacterial infections caused by susceptible organisms. At first, β-lactam antibiotics were mainly active only against gram-positive bacteria, yet the recent development of broad-spectrum β-lactam antibiotics active against various gram-negative organisms has increased their usefulness.