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Leishmaniasis can be partly prevented by sleeping under nets treated with insecticide. [2] Other measures include spraying insecticides to kill sandflies and treating people with the disease early to prevent further spread. [2] The treatment needed is determined by where the disease is acquired, the species of Leishmania, and the type of ...
Visceral leishmaniasis (VL), also known as kala-azar (Hindi: kālā āzār, "black sickness") [2] or "black fever", is the most severe form of leishmaniasis and, without proper diagnosis and treatment, is associated with high fatality. [3] Leishmaniasis is a disease caused by protozoan parasites of the genus Leishmania.
Miltefosine, sold under the trade name Impavido among others, is a medication mainly used to treat leishmaniasis and free-living amoeba infections such as Naegleria fowleri and Balamuthia mandrillaris. [4] This includes the three forms of leishmaniasis: cutaneous, visceral and mucosal. [5] It may be used with liposomal amphotericin B or ...
Mucocutaneous leishmaniasis is an especially disturbing form of cutaneous leishmaniasis, because it produces destructive and disfiguring lesions of the face. It is most often caused by Leishmania braziliensis, but cases caused by L. aethiopica have also been described. [10] Mucocutaneous leishmaniasis is very difficult to treat.
Leishmania / l iː ʃ ˈ m eɪ n i ə,-ˈ m æ n-/ [1] is a parasitic protozoan, a single-celled organism of the genus Leishmania that is responsible for the disease leishmaniasis. [2] [3] [4] They are spread by sandflies of the genus Phlebotomus in the Old World, and of the genus Lutzomyia in the New World.
Sodium stibogluconate, sold under the brand name Pentostam among others, is a medication used to treat leishmaniasis. [3] This includes leishmaniasis of the cutaneous, visceral, and mucosal types. [4] Some combination of miltefosine, paromomycin and liposomal amphotericin B, however, may be recommended due to issues with resistance.
The logo of the Drugs for Neglected Diseases initiative (DNDi) The Drugs for Neglected Diseases initiative (DNDi) is a collaborative, patients' needs-driven, non-profit drug research and development (R&D) organization that is developing new treatments for neglected diseases, notably leishmaniasis, sleeping sickness (human African trypanosomiasis, HAT), Chagas disease, [1] malaria, filarial ...
The first pentavalent antimonial, urea stibamine, was synthesised by the Indian scientist Upendranath Brahmachari in 1922. Though it caused a dramatic decline in deaths due to leishmaniasis, it fell out of favour in the 1950s due to higher toxicity compared to sodium stibogluconate.