Search results
Results from the WOW.Com Content Network
Axonal transport, also called axoplasmic transport or axoplasmic flow, is a cellular process responsible for movement of mitochondria, lipids, synaptic vesicles, proteins, and other organelles to and from a neuron 's cell body, through the cytoplasm of its axon called the axoplasm. [1] Since some axons are on the order of meters long, neurons ...
Anterograde tracing. In neuroscience, anterograde tracing is a research method that is used to trace axonal projections from their source (the cell body, or soma) to their point of termination (the synapse). A hallmark of anterograde tracing is the labeling of the presynaptic and the postsynaptic neuron (s). The crossing of the synaptic cleft ...
Axoplasm is the cytoplasm within the axon of a neuron (nerve cell). For some neuronal types this can be more than 99% of the total cytoplasm. [1] Axoplasm has a different composition of organelles and other materials than that found in the neuron's cell body (soma) or dendrites. In axonal transport (also known as axoplasmic transport) materials ...
Anterograde transport is often the transportation from the cell body to the periphery of the neuron whereas retrograde transport brings organelles and vesicles away from the axon terminus to the cell body. Anterograde transport is regulated by kinesins, a class of motor proteins. Kinesins have two head domains which work together like feet ...
Viral neuronal tracing. Appearance. Viral neuronal tracing is the use of a virus to trace neural pathways, providing a self-replicating tracer. Viruses have the advantage of self-replication over molecular tracers but can also spread too quickly and cause degradation of neural tissue.
All of these functions rely on dynein's ability to move towards the minus-end of the microtubules, known as retrograde transport; thus, they are called "minus-end directed motors". In contrast, most kinesin motor proteins move toward the microtubules' plus-end, in what is called anterograde transport.
Dying back of an axon can also take place in many neurodegenerative diseases, particularly when axonal transport is impaired, this is known as Wallerian-like degeneration. [54] Studies suggest that the degeneration happens as a result of the axonal protein NMNAT2, being prevented from reaching all of the axon. [55]
Retrograde signaling. Retrograde signaling in biology is the process where a signal travels backwards from a target source to its original source. For example, the nucleus of a cell is the original source for creating signaling proteins. During retrograde signaling, instead of signals leaving the nucleus, they are sent to the nucleus. [ 1 ]