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Cold sensitivity or cold intolerance is unusual discomfort felt by some people when in a cool environment. [ 1 ] Cold sensitivity may be a symptom of hypothyroidism , anemia , low body weight, iron deficiency , vitamin B 12 deficiency , fevers , fibromyalgia or vasoconstriction . [ 2 ]
“Women who are menstruating, pregnant women, and people with chronic health conditions are often most at risk for anemia.” Unfortunately, some doctors don’t dig deep enough for answers.
Cold agglutinins, or cold autoantibodies, occur naturally in nearly all individuals. These natural cold autoantibodies occur at low titers, less than 1:64 measured at 4 °C, and have no activity at higher temperatures. Pathologic cold agglutinins occur at titers over 1:1000 and react at 28-31 °C and sometimes at 37 °C.
Secondary cold agglutinin syndrome occurs when autoantibodies bind to red blood cells, rendering them subject to attack by the complement system. [17] It is a result of an underlying condition potentially associated with either monoclonal cold-reacting autoantibodies or polyclonal cold-reacting autoantibodies [16] predominantly caused by infection or lymphoproliferative disorders. [16]
There is no vaccine for the common cold, which is caused by rhinoviruses. But with all respiratory viruses, people can make sure to dress appropriately with hats and gloves in the cold ...
Anemia affects 27% of the world's population with iron-deficiency anemia accounting for more than 60% of it. [116] A moderate degree of iron-deficiency anemia affected approximately 610 million people worldwide or 8.8% of the population. [14] It is somewhat more common in females (9.9%) than males (7.8%). [14]
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Cold agglutinins are antibodies, typically immunoglobulin M (), that are acquainted with and then binding the antigens on red blood cells, typically antigens "I" or "i" on the RBC surface, [1] in the environment in which the temperatures are lower than normal core body temperature and, thus, ends up leading to agglutinations of the red blood cells and hemolysis reaction occurring outside the ...