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Histidine ball and stick model spinning. Histidine (symbol His or H) [2] is an essential amino acid that is used in the biosynthesis of proteins.It contains an α-amino group (which is in the protonated –NH 3 + form under biological conditions), a carboxylic acid group (which is in the deprotonated –COO − form under biological conditions), and an imidazole side chain (which is partially ...
A polyhistidine-tag, best known by the trademarked name His-tag, is an amino acid motif in proteins that typically consists of at least six histidine (His) residues, often at the N- or C-terminus of the protein. It is also known as a hexa histidine-tag, 6xHis-tag, or His6 tag.
In molecular biology, a response regulator is a protein that mediates a cell's response to changes in its environment as part of a two-component regulatory system.Response regulators are coupled to specific histidine kinases which serve as sensors of environmental changes.
The triad is exemplified by chymotrypsin, [c] a model serine protease from the PA superfamily which uses its triad to hydrolyse protein backbones. The aspartate is hydrogen bonded to the histidine, increasing the pK a of its imidazole nitrogen from 7 to around 12. Histidine is thus able to act as a powerful general base, activating the serine ...
This family of HATs contain HAT domains that are approximately 500 residues long and contain bromodomains as well as three cysteine-histidine rich domains that help with protein interactions. [9] These HATs are known to acetylate all of the histone subunits in the nucleosome.
In orthodox two-component signaling, a histidine kinase protein autophosphorylates on a histidine residue in response to an extracellular signal, and the phosphoryl group is subsequently transferred to an aspartate residue on the receiver domain of a response regulator. In phosphorelays, the "hybrid" histidine kinase contains an internal ...
3273 94175 Ensembl ENSG00000113905 ENSMUSG00000022877 UniProt P04196 Q9ESB3 RefSeq (mRNA) NM_000412 NM_053176 RefSeq (protein) NP_000403 NP_444406 Location (UCSC) Chr 3: 186.66 – 186.68 Mb Chr 16: 22.77 – 22.78 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Histidine-rich glycoprotein (HRG) is a glycoprotein that in humans is encoded by the HRG gene. The HRG protein is produced ...
The enzyme histidine decarboxylase (EC 4.1.1.22, HDC) is transcribed on chromosome 15, region q21.1-21.2, and catalyzes the decarboxylation of histidine to form histamine. In mammals, histamine is an important biogenic amine with regulatory roles in neurotransmission , gastric acid secretion and immune response .