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Rosuvastatin, sold under the brand name Crestor among others, is a statin medication, used to prevent cardiovascular disease in those at high risk and treat abnormal lipids. [6] It is recommended to be used together with dietary changes, exercise, and weight loss. [6] It is taken orally (by mouth). [6]
Statins with shorter half-lives are more effective when taken in the evening, so their peak effect occurs when the body's natural cholesterol production is at its highest. A recent meta-analysis suggested that statins with longer half-lives, including atorvastatin, may also be more effective at lowering LDL cholesterol if taken in the evening. [40]
Common side effects include liver problems, breathing problems, abdominal pain, muscle problems, and nausea. [3] Serious side effects may include toxic epidermal necrolysis, rhabdomyolysis, gallstones, and pancreatitis. [3] Use during pregnancy and breastfeeding is not recommended. [6] [7] It works by multiple mechanisms. [3]
Cholesterol synthesis appears to occur mostly at night, [140] so statins with short half-lives are usually taken at night to maximize their effect. Studies have shown greater LDL and total cholesterol reductions in the short-acting simvastatin taken at night rather than the morning, [ 141 ] [ 142 ] but have shown no difference in the long ...
Pravastatin, sold under the brand name Pravachol among others, is a statin medication, used for preventing cardiovascular disease in those at high risk and treating abnormal lipids. [5] It is suggested to be used together with diet changes, exercise, and weight loss. [5] It is taken by mouth. [5]
The researchers looked at 406 prescription medications and found that, as a whole, most drugs were linked to a shorter lifespan — likely because of the effect of the disease that the medication ...
The Heart Protection Study evaluated the effects of simvastatin in people with risk factors including existing cardiovascular disease, diabetes, or stroke, but having relatively low LDL cholesterol. In this trial, which lasted 5.4 years, overall mortality was reduced by 13% and cardiovascular mortality was reduced by 18%.
Since conditions during pregnancy will have long-term effects on adult health, "moderation" should be considered for both dietary and physical activity recommendations. Most importantly, the total recommended pregnancy weight gain depends on pre-pregnant body weight, and weight issues should be addressed before pregnancy.