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Post-exertional malaise (PEM), sometimes referred to as post-exertional symptom exacerbation (PESE) [1] or post-exertional neuroimmune exhaustion (PENE), [2] is a worsening of symptoms that occurs after minimal exertion. It is the hallmark symptom of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and common in long COVID and ...
The fatigue must have lasted for 6 months or longer, and be present at least 50% of the time; Other symptoms are possible, such as muscle pain, mood problems, or sleep disturbance; Conditions known to cause severe fatigue and some mental conditions exclude a diagnosis. Post-infectious fatigue syndrome also requires evidence of a prior infection ...
[2]: 12, 57, 95 [31] [32] The fatigue experienced in ME/CFS is of a longer duration and greater severity than in other conditions characterized by fatigue. [10]: 5–6 The hallmark feature of ME/CFS is a worsening of symptoms after exertion, known as post-exertional malaise or post-exertional symptom exacerbation. [6]
Delayed onset muscle soreness (DOMS) is the pain and stiffness felt in muscles after unaccustomed or strenuous exercise. The soreness is felt most strongly 24 to 72 hours after the exercise. [1] [2]: 63 It is thought to be caused by eccentric (lengthening) exercise, which causes small-scale damage (microtrauma) to the muscle fibers. After such ...
Exercise intolerance is a condition of inability or decreased ability to perform physical exercise at the normally expected level or duration for people of that age, size, sex, and muscle mass. [1] It also includes experiences of unusually severe post-exercise pain, fatigue, nausea, vomiting or other negative effects.
The combination of an inappropriate rapid heart rate response to exercise with heavy or rapid breathing is known as an exaggerated cardiorespiratory response to exercise. [3] Due to the confusion between muscle fatigue and muscle weakness, there have been instances of abnormal muscle fatigue being described as exercise-induced muscle weakness.
Central fatigue is a reduction in the neural drive or nerve-based motor command to working muscles that results in a decline in the force output. [3] [4] [5] It has been suggested that the reduced neural drive during exercise may be a protective mechanism to prevent organ failure if the work was continued at the same intensity.
Prolonged fatigue is fatigue that persists for more than a month, and chronic fatigue is fatigue that lasts at least six consecutive months, which may be caused by a physical or psychological illness, or may be idiopathic (no known cause). [1] Chronic fatigue with a known cause is twice as common as idiopathic chronic fatigue. [6]