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A Jarisch–Herxheimer reaction is a sudden and typically transient reaction that may occur within 24 hours of being administered antibiotics for an infection by a spirochete, including syphilis, leptospirosis, Lyme disease, and relapsing fever. [1]
The reaction generally includes a constellation of fever; urticarial polycyclic wheals (a rash that can look similar to hives with small swellings that overlap each other [2]) with central clearing on the trunk, extremities, face, and lateral borders of the hands and feet; oral edema without mucosal involvement; lymphadenopathy; arthralgias; myalgias; and mild proteinuria.
Drugs can also cause hair and nail changes, affect the mucous membranes, or cause itching without outward skin changes. [ 3 ] The use of synthetic pharmaceuticals and biopharmaceuticals in medicine has revolutionized human health, allowing us to live longer lives.
The rash is red and patchy, but can also cause a sore throat, headache, nausea, vomiting, swollen glands, fatigue, muscle aches, and redness or swelling of the tongue and throat, he explains.
The bacteria releases a toxin that causes a bright red blotchy rash that has a sandpaper-like texture, and the rash can spread to the entire body and usually first appears on the groin, neck, and ...
These 23 skin rash pictures and expert tips can help you decipher your skin. ... almost every day," she adds. The condition causes inflamed patches of skin that can look like a rash, Elbuluk says ...
The diagnosis of AGEP may be forthright in typical cases in which an individual: has taken a drug known to cause the disorder; develops multiple sterile pustules overlying large areas of red swollen skin starting a few days after initial drug intake; and has a histology of biopsied lesions that shows pustules just below the skin's Stratum ...
Between 3 and 10% of children taking amoxicillin (or ampicillin) show a late-developing (>72 hours after beginning medication and having never taken penicillin-like medication previously) rash, which is sometimes referred to as the "amoxicillin rash". The rash can also occur in adults and may rarely be a component of the DRESS syndrome. [48]