Search results
Results from the WOW.Com Content Network
Staphylococcus aureus is a gram-positive spherically shaped ... human factors. [15] Though S. aureus has quick ... of bacterial virulence in S. aureus is ...
Panton–Valentine leukocidin (PVL) is one of many toxins associated with S. aureus infection. Because it can be found in virtually all CA-MRSA strains that cause soft-tissue infections, it was long described as a key virulence factor, allowing the bacteria to target and kill specific white blood cells known as neutrophils. This view was ...
Further findings show that the main virulence factor of S. aureus, the pore-forming toxin α-hemolysin (Hla), is the secreted factor responsible for the activation of an alternative autophagic pathway. It has been demonstrated that this autophagic response is inhibited by artificially elevating the intracellular levels of cAMP. [18]
For example, clumping factor B is a surface protein that is responsible for the binding of fibrinogen around the bacterium to hide it within a clot. [5] [11] Aureolysin is responsible for the cleavage of clumping factor B, which causes the loss of S. aureus binding to fibrinogen. By this mechanism, it may act as a self-regulatory mechanism for ...
Examples of virulence factors for Staphylococcus aureus are hyaluronidase, protease, coagulase, lipases, deoxyribonucleases and enterotoxins. Examples for Streptococcus pyogenes are M protein , lipoteichoic acid , hyaluronic acid capsule, destructive enzymes (including streptokinase , streptodornase , and hyaluronidase ), and exotoxins ...
The system is involved variably in one type of gliding motility, in the proper targeting of certain virulence factors to the cell surface, and the degradation of complex of biopolymers. [39] T9SS has also been known as Por (porphyrin accumulation on the cell surface) secretion, [ 4 ] after the oral pathogen Porphyromonas gingivalis .
The first S. aureus genomes to be sequenced were those of N315 and Mu50, in 2001. Many more complete S. aureus genomes have been submitted to the public databases, making it one of the most extensively sequenced bacteria. The use of genomic data is now widespread and provides a valuable resource for researchers working with S. aureus.
Clumping factor A, or ClfA, is a virulence factor from Staphylococcus aureus (S. aureus) that binds to fibrinogen. ClfA also has been shown to bind to complement regulator I protein. [1] It is responsible for the clumping of blood plasma observed when adding S. aureus to human plasma. Clumping factor can be detected by the slide test.