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Meta-analysis of clinical trials has shown this combined therapy to be more effective than either of its ingredients by themselves. [6]The use of adapalene/benzoyl peroxide in combination with oral antibiotics (lymecycline) has been studied; [7] the combination was well tolerated and showed an improved success rate compared to those receiving only antibiotics (47.6% vs. 33.7%, P = 0.002).
Adapalene, sold under the brand name Differin among others, is a third-generation topical retinoid primarily used in the treatment of mild-moderate acne, and is also used off-label to treat keratosis pilaris as well as other skin conditions. [6]
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The Royal Canadian Pacific is a luxury excursion passenger train operated by Mount Stephen Properties, a wholly owned subsidiary of the Canadian Pacific Railway and later CPKC Railway. It made its first run on June 7, 2000, after the CPR received the royal designation for the service from Elizabeth II , Queen of Canada .
The train runs between Stettler and Big Valley. The trips last five to six hours, with a stopover (all excursions include a buffet meal). Many trains [1] are pulled by No. 41, a 1920 Baldwin 2-8-0 steam locomotive, and sometimes by CN U-1-f No. 6060, a Montreal Locomotive Works 4-8-2.
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Festival Express is a 2003 British documentary film about the 1970 train tour of the same name across Canada taken by some of North America's most popular rock bands, including Grateful Dead, Janis Joplin, The Band, Buddy Guy, Flying Burrito Bros, Ian & Sylvia's Great Speckled Bird, Mountain and Delaney & Bonnie & Friends. [2]
The Rocky Mountaineer and Royal Canadian Pacific provide luxury rail tours for viewing scenery in the Canadian Rockies as well as other mountainous areas of British Columbia and Alberta. Canada has 49,422 kilometres (30,709 mi) total trackage, of which only 129 kilometres (80 mi) is electrified (all urban rail transit networks).
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